多聚ADP核糖聚合酶-1与糖尿病血管并发症

Roles of poly（ADP-ribose） polymerase activation in the pathogenesis and progression of diabetic vascular compfications

多聚ADP核糖聚合酶（PARP）1是PARP核酶家族主要成员,分布广泛,是机体修复DNA损伤的关键酶之一,但其过度激活又会造成细胞的死亡。糖尿病时的氧化应激状态可以造成血管内皮细胞内源性DNA损伤,从而大量激活PARP,进而导致内皮细胞的死亡。这是糖尿病大血管和微血管并发症发生的共同机制。抑制PARP可有效防止内皮细胞的损伤,预防甚至逆转糖尿病血管并发症,对PARP的干预可能成为防治糖尿病血管并发症的一个新靶点。

Poly（ADP-ribese） polymerase （PARP）-1 is an important member of the PARP enzyane family which distributes many tissues. It is the key enzyme in repairing the mild injured DNA. Over-stimulation of PARP caused by severe DNA damage may lead to cell death. Under diabetic status, oxidative stress is the main cause of endogenous DNA damage which makes the PARP over-stimulation, then leading to cell death. It is the common mechanism in the development of diabetic macro- and micro-vascular diseases. It is found that inhibition of PARP may effectively protect endothelium from diabetic vascular diseases. The inhibitors of PARP may become a new strategy in the prevention of diabetic complications.