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肌浆／内质网Ca^2＋—ATP酶与糖尿病心肌病 被引量：2

Sarcoplasmic/endoplasmic reticulmn caicimn ATPases and diabetic cardiomyopathy
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摘要 肌浆/内质网Ca^2＋-ATP酶（SERCA）是离子泵P型家族中的成员。作为钙泵,可调节钙离子浓度及肌肉兴奋-收缩反应。高血糖以及胰岛素抵抗状态下SERCA的活性下降,许多试验证明SERCA参与了糖尿病心肌病心脏功能的变化（包括心肌收缩和舒张功能）,同时伴随受磷蛋白水平和ryanodine受体水平的改变。对SERCA的研究为应用胰岛素等治疗糖尿病心肌病提供了一个新的治疗思路。 The sareoplasmie/endoplasmie retieulum calcium ATPases （SERCA） are members of the P-type family of ion pumps. SERCA can regulate calcium concentrations and excitation-contraction coupling in muscles. Hyperglycaemia and insulin resistance can reduce the activity of SERCA. Many experiments proved that SERCA participates in the change of cardiac function of diabetic cardiomyopathy, accompanying with the alteration of the level of phospholamban and ryanodine recepter. The research of SERCA provides a novel method for treating diabetic cardiomyopathy by using insulin.
作者 晋瑞 王惠芳
机构地区 西安交通大学医学院附属第一医院老年内分泌科
出处 《国际内分泌代谢杂志》 2007年第3期181-183,共3页 International Journal of Endocrinology and Metabolism
关键词 肌浆/内质网Ca^2+-ATP酶 糖尿病 心肌病 胰岛素 Sarcoplasmic/endoplasmic reticulum calcium ATPases Diabetes mellitus Cardiomyopathy Insulin
分类号 R587 [医药卫生—内分泌] R542 [医药卫生—心血管疾病]
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参考文献15

  • 1蒋彬,周希平,蒋文平.钠-钙交换与慢性心力衰竭[J].心血管病学进展,2002,23(6):371-374. 被引量：7
  • 2Mackiewicz U, Lewartowski B. Temperature dependent contribution of Ca^2+ transporters to relaxation in cardiac myocytes:important role of sarcolemmal Ca^2+ -ATPase. J Physiol Pharmacol,2006,57 : 3-15.
  • 3Hiranandani N, Bupha-Intr T, Janssen PM, et al. SERCA overexpression reduces hydroxyl radical injury in murine myocardium. Am J Physiol Heart Circ Physiol,2006,291 :H3130-H3135.
  • 4Wold LE, Dutta K, Mason MM, et al. Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats. J Mol Cell Cardiol, 2005,39: 297-307.
  • 5Trost SU, Belke DD, Bluhm WF, et al. Overexpression of the sarcoplasmic reticulum Ca^2+ -ATPase improves myocardial contractility in diabetic cardiomyopathy. Diabetes, 2002,51 : 1166-1171.
  • 6Vetter R, Rehfeld U, Reissfelder C, et al. Transgenic overexpression of the sarcoplasmic reticulum Ca^2+ ATPase improves reticular Ca^2+ handling in normal and diabetic rat hearts. FASEB J,2002,16:1657-1659.
  • 7Netticadan T,Temsah RM, Kent A, et al. Depressed levels of Ca^2+ -cycling proteins may underlie sarcoplasmic reticulum dysfunction in the diabetic heart. Diabetes,2001,50:2133-2138.
  • 8Vasanji Z, Dhalla NS, Netticadan T. Increased inhibition of SERCA2 by phospholamban in the type 1 diabetic heart. Mol Cell Biochem, 2004,261 : 245 -249.
  • 9Zhou BQ, Hu SJ, Wang GB. The analysis of ultrastructure and gene expression of sarco/endoplasmic reticulum calcium handling proteins in alloxan-induced diabetic rat myocardium. Acta Cardiol,2006,61:21-27.
  • 10Ziegelhoffer-Mihalovicova B, Waczulikova I, Sikurova L, et al. Remodelling of the sarcolemma in diabetic rat hearts:the role of membrane fluidity. Mol Cell Biochem,2003,249:175-182.

二级参考文献10

  • 1于德民,吴锐,尹潍,袁咏.实验性链脲佐菌素糖尿病动物模型的研究[J].中国糖尿病杂志,1995,3(2):105-109. 被引量：425
  • 2施志明,钱晓明,许瑞吉,周晓军,陈云,章俐,吴振国.实验性糖尿病大鼠心肌ATⅡ和心肌超微结构的研究[J].中国糖尿病杂志,1996,4(1):28-30. 被引量：39
  • 3Ren J, Walsh MF, Hamaty M, et al. Altered inotropic response to insulin-like growth factor I in diabetic rat heart:influence of intracellular Ca^2+ and nitric oxide. Am J Physiol, 1998,275(3 Pt 2) :H823.
  • 4Porte D Jr. β-cells in type 2 diabetes mellitus. Diabetes,1991,40(2) :166.
  • 5Davidoff A J, Ben J. Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes. Am J Physiol,1997, 272(1 Pt 2) :H159.
  • 6Ren J, Gintant GA, Miller RE et al. High extraeellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner. Am J Physiol, 1997,273(6 Pt 2) :H2 876.
  • 7Russ M, Reinauer H, Eckel J. Diabetes-induced decrease in the mRNA coding for sarcoplasmic reticulum Ca^2+-AT-Pase in adult rat cardiomyocytes. Biochem Biophys Res Comm, 1991,178(3) :906.
  • 8Hattori Y, Matsuda N, Kinura J, et al. Diminished function and expression of the cardiac Na^2+-Ca^2+ exchanger in diabetic rats: implication in Ca^2+ overload. Physiol, 2000,527(1):85.
  • 9Haak T, Jungmann E, Felber A. Increased plasma levels of endothelin in iabetic patients with hypertension. Am J Hypertens, 1992,5 ( 3 ) : 161.
  • 10任骏.糖尿病心肌病的基础与临床研究现状[J].心血管病学进展,2001,22(5):299-302. 被引量：32

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国际内分泌代谢杂志
2007年 第3期

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