维生素D内分泌系统与骨质疏松

Vitamin D endocrine system and osteoporosis

钙代谢紊乱是引起骨质疏松的直接原因。钙调激素、钙转运蛋白、维生素D代谢酶等所构成的维生素D内分泌系统,在体内的主要作用是调控钙代谢,维持钙平衡。在增龄、性激素水平下降、营养缺乏、药物、制动等各种诱因所致骨质疏松症中,维生素D内分泌系统发生着适应性及病理性变化,并介导骨质疏松的发生、发展。从细胞、分子水平对维生素D内分泌系统的研究,可进一步阐明骨质疏松发生的分子机制,为防治骨质疏松提供新的思路。

The disturbance of calcium is the direct cause for osteoporosis. Vitamin D endocrine system, including calciotropic hormones, Ca-transporting proteins, vitamin D metabolism enzymes, plays a major role in the regulation of the metabolism and the homeostasis of calcium. Adaptive and pathological changes of the vitamin D endocrine system should be focused on the occurrence and development of osteoporosis induced by different factors, such as ageing, sex hormone deficiency, nutritional deficiency, drugs, and immobilization. The study on the vitamin D endocrine system from the view of cell and molecule levels will be helpful in revealing the molecular mechanisms of osteoporosis, and will provide us a new way to prevent and treat osteoporosis.