缝隙连接重构和室性心律失常

Gap Junction Remodelling and Ventricular Arrhythmia

缝隙连接是心肌细胞间直接联系并交换信息的重要途径,在许多心脏疾病中,心肌组织都有缝隙连接的改变,即缝隙连接的重构。缝隙连接的含量、分布及自身磷酸化状态的改变与室性心律失常的发生密切相关。缝隙连接重构与电重构和自主神经之间可能有密切关系。仅仅应用以缝隙连接为靶点的抗心律失常的药物可能是不够的。

Gap junction is the important pathway of communication among myocardial cells, In many cases of heart disease,gap junctions of the myocardium are altered,and this is known as gap junction remodelling, Alterations in the content ,distribution and phosphorylation status of gap junctions are correlated with ventricular arrhythmia, Gap junction remodelling may be correlated with electrical remodelling and autonomic nerve activity, The use of antiarrhythmic peptide only may be not sufficient to induce anti-arrhythmia.