多原发癌128例临床分析

Clinical analysis for 128 patients with multiple primary carcinomas

目的：探讨多原发癌（multiple primary carcinoma，MPC）的临床特点、预后及与原发癌的关系。方法：对1993年7月～2003年6月治疗的128例MPC患者进行回顾性分析。结果：同时性MPC41例，异时性MPC87例，双原发癌113例，三原发癌12例，四原发癌3例。先证癌发病高低顺序为头颈部、消化系统、乳腺、肺。先证癌中男性患者以头颈部、消化系统肿瘤为主，女性以乳腺、头颈部肿瘤为主。重复癌的发病高低顺序为消化系统、头颈部、肺、乳腺等。结论：重视MPC的可能性，尤其是头颈部和消化系统肿瘤。对于诊断明确的MPC应予以根治性治疗。

Objective： To analyze the incidence of multiple primary carcinomas. Methods： Records of 128 patients with multiple primary carcinomas during ten years period between July 1993 and June 2003 were reviewed. Results：One hundred and twenty-eight patients with multiple primary carcinomas were observed. Among them, 113 patients had double primary carcinomas, 12 had triple primary carcinomas ,and 3 had quadruple primary carcinomas. The ratio of male to female was 2.28： 1. The average age was 58.4 years old. There were 41 synchronous carcinomas and 87 metachronous ones. The cancers in decreasing sequence were head and neck region 〉 digestive 〉 breast 〉 lung. Conclnsions：The possibility of multiple primary carcinomas should be emphasized, especially in head and neck cancer patients and digestive cancer patients. When diagnosis is definite,the radical therapy should be performed.