摘要
次级淋巴组织趋化因子（SLC）是近年发现的一种新的趋化因子,高表达于次级淋巴组织,能趋化并活化T淋巴细胞、树突状细胞和自然杀伤细胞等免疫效应细胞,在机体淋巴细胞的迁移归巢、抗肿瘤、抗感染过程中具有重要作用。CCR7是SLC的高亲和力受体,近年来研究发现,CCR7和SLC的表达与肿瘤的淋巴转移密切相关。现综述SLC及其受体CCR7的生物学特性和主要功能,并重点阐述SLC和CCR7在肿瘤侵袭和淋巴转移中的研究现状。
Secondary lymphoid-tissue chemokine （SLC）is a recently identified CC chemokine that is highly expressed in secondary lymphoid tissues and it can chemoattract and activate T lymphocytes, dendritic cells and natural killer cells. It plays an important role in the process of lymphocyte immigration and hoing, anti-tumor and anti-infection. CCR7 is the high affinity receptor of SLC. There is a close correlation between the expression of CCR7 and SLC and tumor lymphatic metastasis. This article describes the bionomics and functions of SLC and CCR7, and reviews the advances of SLC and its receptor CCR7 in tumor invasion and lymphatic metastasis.
出处
《国际外科学杂志》
2007年第5期349-354,共6页
International Journal of Surgery
基金
国家自然科学基金资助项目（No.30571712）、山东省优秀中青年科学家科研奖励基金资助项目（No.2005BS03003）、山东省卫生厅资助项目（No.2005-169）
