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肺表面活性物质预防早产儿呼吸窘迫综合征临床观察 被引量:2

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摘要 目的:研究应用肺表面活性物质(PS)预防早产儿呼吸窘迫综合征(NRDS)的临床价值。方法:14例高危早产儿气管内滴注单剂预防量PS,与14例未应用PS的高危早产儿进行前瞻性临床对照研究。结果:治疗组血气指标改善较对照组明显,治疗组平均住院天数23.3±6.7d,氧疗时间5.1±2.2d,机械通气时间2.6±1.3d;对照组平均住院天数29.6±8.5d,氧疗时间6.9±2.4d,机械通气时间4.7±1.5d,两组比较有显著性差异(P<0.05)治疗组并发NRDS、死亡及需要机械通气例数也较对照组少,但两组无显著性差异(P>0.05)。结论:早产儿预防性应用PS不能降低NRDS发病率及病死率,但可明显改善患儿血气指标,并且缩短住院天数、氧疗时间及机械通气时间。
作者 刘世平
出处 《陕西医学杂志》 CAS 北大核心 2007年第5期601-603,共3页 Shaanxi Medical Journal
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参考文献3

  • 1Enhorning C,Shennan A,Possmayer F,et al.Prevention of neonatai respiratory distress syndrome by tracheal instillation of surfactant:a randomized clinical trial[J].Pediatrics,1985,76:145~153
  • 2Kattwinkel J,Bloom BT,Delmore P,et al.Prophylactic adminstraton of calflung surfactant extract ismore effective than early treatment of respiratatory die-tress syndrome in neonates of 29 though 32 weeks,gestation[J].Pediatrics,1993,92:90~98
  • 3周晓光,罗先琼,杨琳琳,陈运彬,张小庄,赵庆国.肺表面活性物质预防早产儿呼吸窘迫综合征的临床研究[J].中国当代儿科杂志,2001,3(4):387-390. 被引量:17

二级参考文献8

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