微波催化新型杂环基苯并咪唑杀菌剂的合成、表征及活性测定

Ferrocenesulfonyl Benzimidazole Derivatives Synthesized under Microwave Irradiation and Their Crystal Structure and Antimicrobial Activity

以邻苯二胺及相应羧酸为原料,经环化、二茂铁磺酰化,合成了4种未见文献报道的二茂铁磺酰基苯并咪唑衍生物,经元素分析、MS、1H NMR测试技术确证结构。通过X射线衍射,测定了化合物4b的晶体结构,该晶体属单斜晶系,空间群P2(1)/c。晶胞参数:a=0.983 45(6)nm,b=1.702 37(11)nm,c=1.180 96(7)nm,α=90°,β=100.998(4)°,γ=90°,V=1.144 3(2)nm3,Z=4,F(000)=1 744,Mr=443.30,Dc=1.517 g/cm3,R1=0.098 3,wR2=0.110 1。通过琼脂稀释法初步测定了目标化合物4a～4d的杀菌活性,并与商品化的苯并咪唑杀菌剂麦穗宁进行对照试验。结果表明,化合物4a～4d具有良好的杀菌活性,其中化合物4d杀菌活性最高,对5个被测菌种的EC50在17.12～37.11 mg/L。

Four Benzimidazole ferrocenesulfonyl derivatives were prepared by the reaction of ferrocenesulfonylchloride with the corresponding benzimidazoles under microwave irradiation. The compounds were characterized by means of elemental analysis, MS and t H NMR. Henna prismatic crystals of compound 4b were obtained, and the crystal structure was determined by virtue of X-ray diffraction. The crystal is monoclinic with space group 172（ 1 ）/c, and the unit cell parameters are a =0. 983 45 （6） nm, b = 1. 702 37（ 11 ） nm, c =1. 180 96（7） nm, α =90°, β=100.998（4）°, γ=90°, V=1. 144 3（2） nm^3, Z=4, F（000） =1 744, Mr =443.30, Dc = 1. 517 g/cm^3, R1 =0. 098 3, wR2 =0. 110 1. The preliminary bioassay results indicate that compounds 4a - 4d have antimicrobial activity to a certain degree. Compound 4d shows excellent activities against 5 kinds of tested fungus at EC50 17. 12 -37. 11 mg/L.