特发性血小板减少性紫癜治疗前后血小板参数的变化

The Changes of Pre- and Post- Treatment of Parameters Platelet with Idiopathic Thrombocytopenic Purpura

目的研究特发性血小板减少性紫癜治疗前后血小板参数的变化。方法对45例ITP患者治疗前后和30例血小板数值正常的住院患者进行血小板计数(BPC)、平均血小板体积(MPV)、血小板分布宽度(PDW)和血小板压积(PCT)测定。结果治疗前,ITP组的BPC、PCT明显降低,与对照组比较有统计学意义(P<0.05)急性ITP(AITP)的PDW、MPV明显增加(P<0.05),慢性ITP(CITP)组PDW、MPV无明显变化(P>0.05);治疗后,AITP组PDW、MPV与对照组比较无明显变化(P>0.05);CITP组BPC、PCT仍明显减少,MPV呈明显增大(P<0.05),PDW呈分布宽度差异性变大。结论血小板参数可作为ITP诊断,病情严重程度的判断指标。

Objective To study the changes of pre- and post- treatment of parameters platdet with idiopathic thrombocytoponic purpura. Methods To use hemocyte autoanalyser to detect the parameters for platelet （BPC, MPC, PDW, PCT） in peripheral blood in 45 ITP patients and 30 inpatients who have standard parameters platelet. Results ① Pre-therapy： the levels of BPS, PCT decreased in AITP and CITP, and there was significant difference between ITP and the control group. The levels of PDW and MPV in AITP were increased com- pared with controls, while there was no difference between the levels of PDW and MPV between the CITP and the control ② Post-treatment： The levels of BPC, PCT, MPV were still markedly different in CITP compared with the control. There was no difference in the levels of MPV, PDW in AITP compared with the control. Conclusions The parameters for platelet may be useful indexes for diagnosing and determining the state of patients with idiopathic thrombocytopenic purpura.