肾素血管紧张素系统3个关键基因多态性与原发性高血压关系研究进展

The Progress on the Study of the Association Between the Rennin Gene Polymorphism and the Essential Hypertension

目的综述肾素血管紧张素系统3个关键基因即血管紧张素原、血管紧张素转换酶及血管紧张素Ⅱ-1型受体基因多态性与原发性高血压关系的研究进展。方法从血管紧张素原,血管紧张素转换酶及血管紧张素Ⅱ-1型受体基因的生物学特征及与原发性高血压关系的实验研究结果两方面进行分析。结果血管紧张素原、血管紧张素转换酶及血管紧张Ⅱ-1型受体是原发性高血压发病的热点基因。结论血管紧张素素原、血管紧张素转换酶及血管紧张素Ⅱ-1型受体基因多态性与原发性高血压关系的研究结果有助于揭示原发性高血压的发病机制,指导临床用药和基因治疗。

Objective To summarize the progress on the study of the association of the three crucial rennin gene polymorphism, the angiotensinogen, angiotensin-converting enzyme gene and angiotensin Ⅱ type 1 receptor gene Al166C, with the essential hypertension. Methods The biological characteristic of the three genes and their association of the rennin gene polymorphism of the angiotensinogen, angiotensin-converting enzyme gene and angiotensin Ⅱtype 1 receptor gene A1166C with the essential hypertension were compared and analyzed. Results Angiotensinogen, angiotensin-converting enzyme gene and angiotensin Ⅱ type 1 receptor gene A1166C might he the hot gene to the essential hypertension. Conclusion The study might help to clarify the mechanism and to direct the medication and gene therapy of the essential hypertension.