Galectin-3在甲状腺良恶性病变中的表达

The expression of Galectin-3 in benign and malignant thyroid lesions

目的探讨Galectin-3在甲状腺病变中的表达及其对于良、恶性甲状腺肿瘤的鉴别价值。方法采用SP免疫组织化学法对99例甲状腺手术切除标本进行Galectin-3的检测。结果67例甲状腺癌中59例表达阳性,阳性率88.1%,阳性细胞弥漫性分布,其中,甲状腺滤泡癌22例(91.7%)、乳头状癌24例(88.9%)、髓样癌10例(83.3%)、未分化癌3例(75.0%)阳性。13例甲状腺乳头状增生中Galectin-3表达全部阴性。19例腺瘤仅3例呈弱阳性(15.8%),阳性细胞呈小灶性分布。良、恶性病变之间比较,差异有高度显著性(P<0.01)。甲状腺癌各组织学类型之间比较,差异无显著性意义(P>0.05)。结论Galectin-3可有效地区别良、恶性甲状腺病变,可作为甲状腺肿瘤的鉴别诊断标志。

Objective To explore the expression of Galectin-3 in thyroid lesions and its value in differentiating benign from malignant lesions. Methods Galectin-3 protein expression in 99 cases of thyroid lesions was studied by streptavidin/peroxidase （SP） immunohistochemistry technique. Results Fifty-nine of the 67 （ 88.1% ） cases of thyroid carcinomas （ 22/24 follicular carcinomas, 24/27 papillary carcinomas, 10/12 medullary carcinomas and 3/4 anaplastic carcinomas ） showed cytoplasmic immunohistochemical staining of Galectin-3 , which was diffuse. As to the group of adenomas （ n = 19 ） , only 3 cases were focally and weakly positive. There was no Galectin-3 expression in 13 cases of thyroid papillary hyperplasia. There was significant difference between the expression of Galectin-3 in malignant thyroid tumors and that in benign lesions（ P 〈 0.01 ） , and no difference between the four histological types of thuroid cnacer （P 〉 0.05 ）. Conclusions Galectin-3 may be useful in the diagnosis of thyroid carcinomas, and it can be regarded as a valuable molecular marker to distinguish benign from malignant lesions.