妊娠晚期妇女凝血及纤溶系统的改变与临床意义

The changes in coagulation and fibrinolytic system in terminal pregnant women and their clinical significance

目的:探讨妊娠晚期妇女凝血及纤溶系统的改变与临床意义。方法:选取180例妊娠晚期(平均孕周37.5周)妇女,检测其血浆中凝血酶原时间(PT),活化全血凝固时间(APTT),纤维蛋白(FIB),D-二聚体(D-Dimer)等4项指标。选取健康非妊娠妇女45例作为对照。结果:妊娠晚期妇女血浆PT,APTT,FIB,D-Dimer值与对照组比较差异均有统计学意义(P<0.05)。结论:妊娠晚期妇女血液处于高凝状态,检测上述4项指标,对防止妊娠晚期血栓形成、妊娠高血压综合征等并发症有一定临床意义。

Objective： To evaluate changes in coagulation and fibrinolytic system in terminal pregnant women and their clinical significance. Methods： The concentrations of PT, APTT, FIB, and D-Dimer in 180 terminal pregnant women and 45 nonpregnant women were determined. Results：PT and APTT shortened in terminal pregnant women, with significant difference between terminal pregnant women and nonpregnant women（ P 〈 0.05 ）. The values of FIB and D-Dimer were higher in pregnant women, with significant difference between nonpregnant women and terminal pregnant women （ P 〈 0.05 ） . Conclusion： Pregnant women are in hypereoagulable state. The coagulation and fibfinolytic system can be applied to monitor thrombosis in pregnant women.