成骨蛋白-1在人牙髓组织中的表达研究

Expression of osteogenic protein-1 in human pulp tissue

目的:探讨成骨蛋白-1在正常人牙髓组织中的免疫定位、分布规律。方法:采用免疫组织化学技术,检测正常人牙髓组织中成骨蛋白-1表达。结果:正常人牙髓组织中成牙本质细胞成骨蛋白-1呈强阳性染色,毛细血管内皮细胞呈阳性表达,邻近成牙本质细胞的少数牙髓细胞可见阳性染色。结论:成骨蛋白-1参与成牙本质细胞的合成和分泌,在诱导新生牙本质样细胞形成和分化过程中可能起重要作用。

AIM： To observe the expression of osteogenic protein - 1 in human pulp tissue. METHODS： Immunochemistry technique was used to detect the osteogenic protein - 1 in human pulp tissue. RESULTS： We found that the odonotblasts are strongly stained. The vascular endothelial cells are strongly immunopositive. A few of pulp cells are weakly stained. CONCLUSION： These results demonstrated that the osteogenic protein - 1 might play an important role in the formation of reparative dentine and mineral formation.