Neuroserpin在神经系统疾病中的实验研究进展
摘要
Neuroserpin(NSP)是一种轴突选择性的神经丝氨酸蛋白酶抑制剂。在成人中枢神经系统内,它主要存在于新大脑皮质、海马结构、嗅球和杏仁核,而在大多数丘脑核、尾状核、壳核和小脑细胞中相对缺乏。在大脑内,NSP形成了十二烷基磺酸钠(SDS)这种稳定的复合物,抑制了组织型纤溶酶原激活剂(tPA)、尿激酶和纤维蛋白溶酶的活性。
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2007年第4期281-283,共3页
Chinese Journal of Neurology
参考文献20
-
1Onda M, Belorgey D, Sharp LK, et al. Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies. J Biol Chem, 2005, 280: 13735- 13741.
-
2Teesalu T, Kulla A, Simisker A, et al. Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Thromb Haemost, 2004, 92:358-368.
-
3Lebeurrier N, Liot G, Lopez-Atalaya JP, et al. The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo. Mol Cell Neurosci, 2005, 30: 552-558.
-
4Yepes M, Sandkvist M, Coleman TA, et al. Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest, 2002, 109: 1571-1578.
-
5Miranda E, Lomas DA. Neuroserpin : a serpin to think about. Cell Mol Life Sci, 2006, 63:709-722.
-
6Simonin Y, Charron Y, Sonderegger P, et al. An inhibitor of serine proteases, neuroserpin, acts as a neuroproteetive agent in a mouse model of neurodegenerative disease. J Neurosci, 2006, 26 : 10614-10619.
-
7Navarro-Yubero C, Cuadrado A, Sonderegger P, et al. Neuroserpin is post-transcriptionally regulated by thyroid hormone. Brain Res Mol Brain Res, 2004, 123: 56-65.
-
8Zhang Z, Zhang L, Yepes M, et al. Adjuvant treatment with nettroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke. Circulation, 2002,106 : 740-745.
-
9Yepes M, Sandkvist M, Wong MK, et al. Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood, 2000, 96: 569-576.
-
10Bradshaw CB, Davis RL, Shrimpton AE, et al. Cognitive deficits associated with a recently reported familial neurodegenerative disease: familial eneephalopathy with neuroserpin inclusion bodies. Arch Neurol, 2001,58: 1429-1434.
-
1周宏伟,曲松滨,王林业,陈士谟.超早期大剂量尿激酶冲击治疗脑梗塞的临床观察[J].黑龙江医学,1998,0(7):34-34.
-
2刘君霞.纤溶酶治疗急性脑梗死的临床疗效观察[J].临床合理用药杂志,2015,8(21):51-52.
-
3李建国.纤溶酶治疗急性脑血栓的临床疗效观察[J].临床合理用药杂志,2014,7(36):37-37. 被引量:4
-
4潘伟民,蒋建设,陆文熊,陈祖煖,万祖根,陆逸仙.急性脑血管病患者血浆组织型纤维蛋白溶酶原激活物及其抑制物水平的变化[J].浙江医学,1993,15(4):211-212. 被引量:1
-
5徐宇伦,王宜崇,蔡卓基,牛德福,贾丽春,阎希威,张军,白勤,陈炳桓,陈学诗,杨炯达.慢性精神分裂症的外科治疗——丘脑背内侧核为主的立体定向毁损术[J].中华神经外科杂志,1991,7(2):115-117. 被引量:2
-
6吴文辉.抑肽酶对脑出血后脑水肿的疗效观察[J].浙江中西医结合杂志,2004,14(9):540-541.
-
7吕学海,李献平,石改平,何俊芳,吴斐,王志刚.银杏叶提取物随氧吸入对急性脑梗死患者血清VEGF、SOD和MDA水平的影响[J].解放军医药杂志,2016,28(B06):55-57. 被引量:14
-
8王小京.大脑深层刺激治疗难以阻断帕金森病的发展[J].国外医学情报,2005,26(11):44-44.
-
9龚颖,龚宇飞,朱红.蚓激酶治疗脑血栓100例临床观察[J].黑龙江医学,1998,0(10):38-38.
-
10杜玉光.纳洛酮、巴曲酶联用治疗大面积脑梗死15例[J].中国现代药物应用,2009,3(3):119-120.