期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

初发2型糖尿病病人短期强化胰岛素治疗胰岛素抵抗改善的可能机制 被引量：38

原文传递
导出
摘要 2型糖尿病（T2DM）患者有90％存在胰岛素抵抗，后者也是T2DM发病的主要病理生理机制。早期研究发现给予短期强化胰岛素治疗可以改善不同病程中T2DM患者的胰岛素抵抗并控制血糖。在1997年Ilkova等对13例经饮食控制疗效欠佳的初发T2DM患者使用强化胰岛素治疗2周，结果9例患者在停药后单纯饮食控制就能维持血糖达标时间达9～50个月。2004年Ryan等报道对严重的初发T2DM患者给予每天多次注射胰岛素的强化治疗2—3周，可以诱导长期的血糖控制。同年，我科翁建平教授等报道对138例初发T2DM患者给予2周的CSII强化治疗后，
作者 毕艳 孙卫平 翁建平
机构地区 广州中山大学附属第一医院内分泌科
出处 《中华医学杂志》 CAS CSCD 北大核心 2007年第18期1284-1286,共3页 National Medical Journal of China
关键词 强化胰岛素治疗 胰岛素抵抗 2型糖尿病 糖尿病病人 初发 可能机制 T2DM 病理生理机制
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献25

  • 1Garvey WT, Olefsky JM, J Griffin. The effect of insulin treatment on insulin secretion and insulin action in type Ⅱ diabetes mellitus. Diabetes, 1985, 34: 222-234.
  • 2Firth RG, Bell PM, Rizza RA. Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulindependent diabetes mellitus. NEJM, 1986, 314 : 1280-1286.
  • 3Ilkova H, Glaser B, Tunckale A. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care, 1997, 20 : 1353-1356.
  • 4Ryan E, Imes S, Wallace MC. Short-term Intensive insulin therapy in newly diagnosed type 2 diabetes. Diabetes care, 2004, 27 : 1028-1032.
  • 5Li YB, Xu W, Liao ZH, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of β-cell Function. Diabetes Care, 2004, 27: 2597-2602.
  • 6李延兵,翁建平,许雯,陈小华,廖志红,姚斌,邓婉萍,欧香忠,胡国亮.短期持续胰岛素输注治疗对初诊2型糖尿病患者胰岛β细胞功能的影响[J].中国糖尿病杂志,2003,11(1):10-15. 被引量：777
  • 7Buren J, Eriksson JW. Is insulin resistance caused by defects in insulin's target cells or by a stressed mind? Diabetes Metab Res Rev, 2005, 21 : 487-494.
  • 8Marshall S, Bacote V, Traxinger RR. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. J Biol Chem, 1991, 266: 4706-4712.
  • 9Proietto J. Mechanisms of insulin resistance caused by nutrient toxicity. Hepatol Res ,2005,33 : 87-91.
  • 10McGarry JD. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes, 2002, 51:7-18.

二级参考文献10

  • 1Purrello F, Rabuazza AM. Metabolic factors that affect betacell function and survival. Diabet Nutr Metab, 2000, 13: 84-91.
  • 2Sivitz WI. Lipotoxieity and glueotoxieity in type 2 diabetes. Effects on development and progression. Postgrad Med, 2001,109: 55-59,63-64.
  • 3Lenhard M J, Reeves GD. Continous subcutaneous insulin infusion: a comprehensive review of insulin pump therapy. Arch Intern Med,2001,161: 2293-2300.
  • 4Dupuy O, Mayaudon H, Palou M, et al. Optimized transient insulin infusion in uneontrolled type 2 Diabetes : Evaluation of a pragmatie attitude. Diabet Med, 2000,26 : 371-375.
  • 5Valensi P, Moura I, Magoarou M,et al. Short-term effects of continuous subcutaneous insulin infusion treatment on insulin secretion in non-insulin-dependent overweight patients with poor glycaemic control despite maximal oral anti-diabetic treatment. Diabet Metab,1997,23: 51-57.
  • 6Lormeau B, Aurousseau MH, Valensi P, et al. Hyperinsulinemia and hypofibrinolysis: effects of short-term optimized glyeemic control with contineuous insulin infusion in type Ⅱ diabetie patients. Metabolism,1997,46: 1074-1079.
  • 7Ilkova H, Glaser B, Tunckale A, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care, 1997,20:1353-1356.
  • 8Pratley RE, Weyer C. The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus. Diabetologia 2001,44:929-945.
  • 9Del Prato S, Marchetti P, Bonadonna RC. Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes,2002, 51suppl 1: s109-116.
  • 10Kahn SE. The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus. Am J Med, 2000,108suppl 6a: 2s-8s.

共引文献776

同被引文献289

引证文献38

二级引证文献235

中华医学杂志
2007年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部