针药结合对中老年男性部分雄激素缺乏综合征患者生殖内分泌的影响

Study on effects of acupuncture combined with medication on reproductive endocrines in the patient of PADAM

目的:观察针药结合对中老年男性部分雄激素缺乏综合征(PADAM)患者生殖内分泌的影响。方法:将60例患者随机分为3组,观察组(针药结合组)、对照1组(单纯针刺组)、对照2组(口服补肾胶囊组),每组各20例。采用放射免疫法分别测定各组患者治疗前后血清睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)的血清浓度水平。结果:治疗后3组患者血清T含量较前有显著性提高(其中观察组提高较为显著,P<0·01);治疗后观察组和对照1组患者血清中LH含量较前有显著性下降(P<0·05),对照2组下降不明显(P>0.05);治疗后观察组患者FSH值较前显著性提高(P<0·05),而对照1组和对照2组无显著性提高(P>0.05);治疗后观察组、对照1组及对照2组患者的症状体征均有显著改善,PADAM评分指数均有所下降,其中以观察组改善最为显著(P<0·01),对照1组、对照2组均为P<0·05。结论:针药结合治疗PADAM具有较好的疗效,能调节下丘脑-垂体-睾丸轴激素的分泌,提高血中的睾酮浓度,改善PADAM患者临床体能、血管舒缩症状、精神心理、性功能减退等临床症状,提高生活质量。

Objective To observe effects of acupuncture combined with medication on reproductive endocrines in the patient of partial androgen deficiency of aging men （PADAM）. Methods Sixty cases conforming to diagnostic criteria of PADAM were randomly divided into 3 groups, an observation group treated by acupuncture combined with medication, a control group Ⅰ by simple acupuncture and a control group Ⅱ by oral administration of Bushen Capsules, 20 cases in each group. Serum levels of testosterone （T）, luteinizing hormone （LH） and follicle stimulating hormone （FSH） before and after treatment were determined with radioimmunoassay. Results After treatment, the serum levels of T in the 3 groups increased significantly, with more significantly increased in the observation group （P〈0. 01）; after treatment, the serum levels of LH in both the observation group and the control group Ⅰ decreased significantly （P〈0.05）, but in the control group Ⅱ did not significantly change （P〉0.05） ; after treatment, FSH content in the observation group significantly increased （P〈0.05）, but in the control group Ⅰ and the control group Ⅱ did not significantly change （P〉0.05） ; after treatment, the symptoms and signs in the 3 groups significantly improved and PADAM indexes decreased significantly （P〈0. 05 or P〈0. 01）. Conclusion Acupuncture combined with medication has a better therapeutic effect on PADAM, and it can regulate secretion of hormones in the hypothalamus-pituitary-testicle axis and can increase blood T level, improve physical ability, vascular function, sexual function and quality of life in the patient of PADAM.