血清CA125检测在腹水性质分析中的诊断价值

Clinical significance of serum CA125 in the diagnosis of ascites

目的探讨血清CA125检测在腹水性质分析中的诊断价值。方法对14例结核性腹膜炎、10例自发性细菌性腹膜炎、29例肝硬化腹水和44例腹膜转移癌患者血清CA125进行检测,并对59例不伴有腹水的腹腔脏器恶性肿瘤患者和20例健康人进行对照。结果腹水患者血清CA125明显高于正常对照组(P<0·01);不同性质腹水患者之间血清CA125无明显差异(P>0·05);不伴有腹水的腹腔脏器恶性肿瘤(包括卵巢癌)患者血清CA125与正常对照组无明显差异(P>0·05);卵巢癌伴腹膜转移者血清CA125高于其他腹膜转移癌(P<0·05)。结论血清CA125检测,对腹水性质无鉴别诊断价值。血清CA125不是卵巢癌特异性标志物,但可作为卵巢癌腹膜转移的标志。

Objective To study the clinical value of serum CA125 in the diagnosis of ascites. Methods Serum CA125 was measured and analyzed in 14 cases with tuberculous peritonitis, 10 cases with spontaneous bacterial peritonitis, 29 cases with liver cirrhosis, 44 cases with peritoneal metastatic carcinoma,59 non-ascites cases with malignant tumors of peritoneal cavity and 20 healthy subjects. Results Serum CA125 in patients with ascites was significantly higher than that in healthy subjects （P〈0.01）. There was no significant difference of serum CA125 concentrations among the cases with ascites of different diseases（P〉0. 05）. Serum CA125 concentrations in non-ascites cases with malignant tumors of peritoneal cavity including ovarian carcinoma were similar to those in healthy subjects （P〉0.05）. The patients with ovarian carcinoma associated with peritoneal metastasis had higher serum CA125 concentrations compared with those with other peritoneal metastatic carcinoma （P〈0. 05）. Conclusion Serum CA125 is of no clinical significance in the differential diagnosis of ascitic aetiology. Serum CA125 is not a specific marker for ovarian carcinoma, but can be taken as a marker for peritoneal metastasis of ovarian carcinoma.