透皮免疫的应用进展

Transcutaneous immunization:New approach of vaccination

近年在新型疫苗投递技术的研究中,透皮免疫已作为一种非注射性免疫的发展方向,已证明是一种简便、安全、有效的免疫途径。现对国外透皮免疫途径的免疫机制、免疫佐剂和在疫苗上的应用进展综述。

Transcutaneous immunization(TCI),a topical vaccine application,combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin,this novel method of vaccine delivery has the potential to provide a convenient,safe and effective strategy for inducing strong mucosal antibody and CTL responses.Now,TCI as immunological mechanism、the adjuvant and broadly applicable approach to vaccination is discussed in the context.