黏膜地址素细胞黏附分子与溃疡性结肠炎

Relationship between mucosal addressin cell adhesion molecule-1 and uicerative colitis

黏膜地址素细胞黏附分子(mucosal addressin cell adhesion molecule-1,MAdCAM-1)是一种选择性表达于肠道黏膜及其相关淋巴组织的血管内皮细胞表面的黏附分子,主要介导淋巴细胞向肠道黏膜部位定向归巢．在溃疡性结肠炎(ulcerative colitis,UC)的炎症部位MAdCAM-1表达明显增加．本文综述MAdCAM-1的分子结构、分布、生物学功能及其在UC发病中的作用,要重视其作为UC潜在治疗靶标的意义．

Mucosal addressin cell adhesion molecule-1 （MAdCAM-1） is an adhesion molecule that is preferentially expressed on the surface of vascular endothelial cells in intestinal tract and associated lymphoid tissues, and it is a major determinant of lymphocyte trafficking to the gut mucosa. The expression of MAdCAM-1 is dramatically increased in the inflammatory sites of ulcerative colitis （UC）. This article reviews the molecular structure, distribution, biological function of MAdCAM-1 and its role in the pathogenesis of UC. It is also emphasized that MAdCAM-1 is a potential therapeutic target in UC.