酒精性肝炎的治疗进展

Advances in treatment of alcoholic hepatitis

酒精性肝炎往往导致肝硬化及肝癌,其重症患者短期死亡率相当高．迄今为止,尚无任何药物可以根治这一顽疾,现有临床治疗仅停留于对病情的缓解和营养补充层次．肝脏移植是酒精性肝炎重症患者最佳的、也是最无奈的选择,但他仍然面临移植手术时机和患者适应症的选择问题．近年随着酒精性肝炎发痛机制的逐渐阐明,揭示了肝细胞凋亡以及各种细胞因子在其病程发展中所扮演的重要角色,由此引发了新一轮寻找酒精性肝炎特效疗法的热潮．

Alcoholic hepatitis is a serious liver disease that may lead to cirrhosis and carcinoma, and the short-term mortality rate is fairly high in severe patients. Various strategies have been tested over the decades and none has shown any consistent benefit but the corticosteroids. Until now hepatic transplantation the patients with severe is the best solution to alcoholic hepatitis, but the timing and indications for transplantation are still problematic. Recent advances in the understanding of alcoholic hepatitis, including the roles of hepatocyte apoptosis, oxidative stress and cytokines, have provided a new opportunity to discover specific therapies for alcoholic hepatitis.