新辅助化疗对乳腺癌超微结构的影响

The effect on ultrastructure in breast cancer of neoadjuvant chemotherapy

目的:探讨新辅助化疗对乳腺癌超微结构的影响。方法:应用电镜观察20例新辅助化疗组和20例对照组乳腺癌细胞超微结构的变化。结果:新辅助化疗组肿瘤细胞超微结构示有不同程度的细胞毒性损伤,新辅助化疗组和对照组线粒体数量、粗面内质网数量差异均有统计学意义(P<0.05)。结论:新辅助化疗可使乳腺癌细胞线粒体损伤数量减少,形态发生改变;使粗面内质网脱颗粒,受损减少。

Objective： To study the effect on ultrastructure in breast carcinoma of neoadjuvant chemotherapy. Method： The uhrastructure of 20 cases of human breast carcinoma after neoadjuvant chemotherapy and the uhrastructure of 20 cases of control group were observed by transmission electron microscope. Results： In neoadjuvant group , the tumor cells showed some noxious injuries. The quantities of mitochondrion in neoadjuvant group were significantly differently from those of control group （P〈0.05）, The quantities of rough endoplasmic reticula in neoadjuvant group were significantly differently from those of control group （P〈0.05）.Conclusion： The neoadjuvant chemotherapy can damnify the mitochondria decrease their number and change their configuration; the neoadjuvant chemotherapy can degranulate the rough endoplasmic reticula and decrease their number.