阿司匹林、双嘧达莫、川芎嗪联合治疗急性脑梗死效果评估

The combined therapeutic effect of Aspirin,Dipyridamole and Tetramethylpyrazi on patients with acute cerebral infarction

目的:观察阿司匹林、双嘧达莫及川芎嗪联合治疗对急性脑梗死患者血小板功能的影响,并对联合治疗的临床疗效和安全性作一简单评估。方法:将急性脑梗死患者66例随机分为观察组和对照组。对照组采用常规治疗加用阿司匹林,观察组在常规治疗基础上行阿司匹林、双嘧达莫及川芎嗪联合治疗。治疗前及治疗后14天分别评定神经功能缺损评分及血小板功能的变化。结果:观察组总有效率84.8%(28/33),对照组63.6%(21/33),两组比较差异有统计学意义(P<0.05);观察组较对照组神经功能缺损评分、血小板功能均有明显的改善(P<0.05)。结论:阿司匹林、双嘧达莫及川芎嗪联合应用治疗急性脑梗死可明显改善血小板功能,提高临床疗效,且与常规治疗有协同作用,无明显副反应。

Objectb;e ：To observe the combined therapeutic effect as well as primarily assessing the clinical curative effect and safety of Aspirin, Dipyridamole and Tetramethylpyrazi on patients with acute cerebral infarction. Methods ： 66 patients with acute cerebral infarction were randomly divided into control group and treatment group. Every patient in control group was given normal medical therapy and aspirin. The patients in treatment group were given the combined treatment of Aspirin, Dipyridamole and Tetramethylpyrazi besides normal medical therapy. The neurological defect score and the function of platelet were evaluated respectively before treatment and on the 14th day after treatment. Results ：The total effective rate in treatment group was 84.8%, at the same time the rate of in control group was 63.6%. There was a significant difference between the two groups （P〈0.05）. The index of treatment group were much better than those of the control group（P〈0.05）. Conclusion ：The combined treatment of Aspirin, Dipyridamole and Tetramethylpyrazi on patients with acute cerebral infarction can obviously improve the function of platelet and enhance the curative effect. What＇s more, the combined treatment produces synergistic effect without yielding side effect.