临床分离菌对19种常用抗菌药物的耐药性监测

Bacterial resistance monitoring of clinical isolates against 19 commonly used antibacteria agents

考察本院1994年5月至1995年4月从临床标本中分离的854株病原菌．前5位排列依次为铜绿假单胞菌、凝固酶阴性葡萄球菌、大肠杆菌、克雷伯氏菌属、金葡球菌、检测它们对19种常用抗菌药物的耐药性及是否含β-内酰胺酶，结果显示多数细菌对亚胺培南、头孢他啶、环丙沙星、阿米卡星的耐药性在10％以下，耐甲氧西林葡萄球菌对绝大多数抗菌药物耐药性在50％以上。定期系统的耐药性监测对监床用药有重要指导意义。

854 bactcria included P. aerginosa, coagulase-nagative staphylococci, E.coli, Klebsiella, S. aureus, isolated from clinical specinlems from May 1994 to April 1995were analysed. Detccted thcir reslstancc to 19 antibactcrial agcnts and β-lactamase. Rcsultsshowed the resistance of many bacteria to imipcnem, ceftazidimc, ciprofloxacin, amikacinwas less than 10%- The rcsistance of MRSA to most antibactcrial agcnts was morc than50%. Resistancy detcction of bacteria periodically has importent significance to clinical drugtreatment.