氩等离子凝固术联合抑酸治疗Barrett食管的临床研究

Clinical study on reversal of Barrett's esophagus with acid suppression and Argon Plasma Coagulation

目的观察氩等离子凝固术(APC)联合抑酸治疗对Barrett食管上皮的逆转作用。方法将86例经内镜和病理确诊的Barrett食管患者随机分为2组,治疗组采取APC联合抑酸治疗,对照组采用抑酸加抗反流治疗。于治疗后第3,6,12个月进行内镜和病理复查,观察2组Barrett食管上皮逆转情况。结果治疗组Barrett食管上皮逆转总有效率3,5,12个月时分别为68%,87%,90%,而对照组分别为0%,2%,13%。2组间总有效率比较有显著性差异(P<0.01)。结论APC联合抑酸治疗对Barrett食管上皮有显著逆转作用。

Objective It is to observe the effect of acid suppression combined with Argon Plasma Coagulation （APC） on reversal of Barrett＇s esophagus＇ endepidermis. Methods 86 patients with Barrett＇s esophagus diagnosed by endoscope and pathology method were randomly divided into two groups. The treatment group was treated with APC combined with acid suppression, and the control group was treated with acid suppression combined with anti-regurgltation. All the patients were rechecked by endoscope and pathology method on the 3rd, 6th and 12th month after treatment to observe the reversal of Barrett＇s esophagus＇ endepldermis. Results The total effective rates of reversal of Barrett＇s esophagus were 68%, 87% and 90% respectively after 3, 6, 12 months＇ treatment in the treatment group, while those were 0%, 2% and 13% in the control group. The difference between the two groups was significant. Conclusion APC combined with acid suppression has an obvious reversal function on Barrett＇s esophagus＇ endepidermis.