摘要
目的:探讨MMP-7表达与卵巢癌生物学行为的关系。方法:采用免疫组化法检测MMP-7在卵巢癌中的表达。结果:在卵巢良性肿瘤MMP-7呈阴性表达;在卵巢癌组织中主要表达于癌细胞膜和胞质中;间质细胞中无表达。在卵巢癌中阳性表达率为42.1%(32/74);MMP-7表达与卵巢癌淋巴结转移,临床分期,静脉侵犯和浸润深度有关(P<0.05);与病理类型,病理分化无关(P>0.05)。结论:MMP-7在卵巢癌进展中有重要作用,可能是一个独立预后指标。常规检测其在卵巢癌中的表达,有助于卵巢癌治疗和预后的判断。
Objective:To investigate the relationship between the MMP-7 expression and the biological behavior in ovarian carcinoma. Methods:Immunohistochemical SABC method was used to detect the MMP -7expression in ovarian carcinoma. Results .Negative MMP-7 expression was found in benign tumor,and MMP-7 was expressed in 42%(32/74) of the tumor mainly in the cytoplasm and the membrane of the tumor cells but not in the interstitial cells. The expression of MMP-7 was associated with lymph node metastasis,clinical stage and infiltration depth,but was not associated with pathological classification and histological grade( P 〉 0. 05 ). Conclusion :MMP-7 expression may play a key role in the progression of ovarian carcinoma and serve as an independent factor of prognosis. Routine detection of MMP- 7 expression may be useful for the prediction of treatment and prognosis in ovarian carcinoma.
出处
《黑龙江医药科学》
2007年第2期15-16,共2页
Heilongjiang Medicine and Pharmacy
关键词
卵巢肿瘤
基质金属蛋白酶
预后
免疫组织化学
ovarian neoplasm
matrix metalloprotcinase- 7
prognosis
immunohistoehemistry