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MMP-7在卵巢癌组织中的表达及其临床意义 被引量:2

Expression of MMP-7 in ovarian carcinoma and its clinical singnificance
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摘要 目的:探讨MMP-7表达与卵巢癌生物学行为的关系。方法:采用免疫组化法检测MMP-7在卵巢癌中的表达。结果:在卵巢良性肿瘤MMP-7呈阴性表达;在卵巢癌组织中主要表达于癌细胞膜和胞质中;间质细胞中无表达。在卵巢癌中阳性表达率为42.1%(32/74);MMP-7表达与卵巢癌淋巴结转移,临床分期,静脉侵犯和浸润深度有关(P<0.05);与病理类型,病理分化无关(P>0.05)。结论:MMP-7在卵巢癌进展中有重要作用,可能是一个独立预后指标。常规检测其在卵巢癌中的表达,有助于卵巢癌治疗和预后的判断。 Objective:To investigate the relationship between the MMP-7 expression and the biological behavior in ovarian carcinoma. Methods:Immunohistochemical SABC method was used to detect the MMP -7expression in ovarian carcinoma. Results .Negative MMP-7 expression was found in benign tumor,and MMP-7 was expressed in 42%(32/74) of the tumor mainly in the cytoplasm and the membrane of the tumor cells but not in the interstitial cells. The expression of MMP-7 was associated with lymph node metastasis,clinical stage and infiltration depth,but was not associated with pathological classification and histological grade( P 〉 0. 05 ). Conclusion :MMP-7 expression may play a key role in the progression of ovarian carcinoma and serve as an independent factor of prognosis. Routine detection of MMP- 7 expression may be useful for the prediction of treatment and prognosis in ovarian carcinoma.
出处 《黑龙江医药科学》 2007年第2期15-16,共2页 Heilongjiang Medicine and Pharmacy
关键词 卵巢肿瘤 基质金属蛋白酶 预后 免疫组织化学 ovarian neoplasm matrix metalloprotcinase- 7 prognosis immunohistoehemistry
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