摘要
正常人或患者外周血、骨髓单个核细胞中定期加入IFN-γ、IL—1、IL-2、CD3mAb经2-4W的诱导可获得大量的新型肿瘤杀伤细胞-细胞因子诱导的杀伤细胞CIK，此细胞增殖旺盛杀伤活性高。CIK在体内和体外都具有非MHC限制抗肿瘤活性，在临床上已经用于治疗多种恶性肿瘤表现出强大的杀瘤活性，是一种很好的免疫治疗方法。
CIK（cytokine-induced killer cells） are generated by incubation of peripheral blood lymphocytes of health adult or patient with anti-CD3 monoclonel antibody （CD3mAb） ,4nterleukin-2 （ IL-2）, interleukin-1 （IL-1） ,and interferon-γ（IFN-γ）. CIK cells have high proliferation and cytotoxic activity. CIK is non-major histocompatibility-restricted antitumor activity in vitro and in vivo. It has been applicated to treat many malignant tumors and indicated that CIK cells were useful in cancer immunotherapy.
出处
《国际免疫学杂志》
CAS
2007年第3期163-166,共4页
International Journal of Immunology
基金
黑龙江省重点攻关课题基金资助（G00C190401）
