非胰岛素依赖性糖尿病肾病病人的血清脂蛋白(a)水平

Relationship between urinary albumin excreation rate and plasma Lp(a) level in patients with non-insulin-dependent diabetes mellitus

本文作者测定132例非胰岛素依赖性糖尿病（NIDDM）的尿白蛋白排泄率（UAER）和血清脂蛋白（a）[Lp（a）]水平。发现，伴大量白蛋白尿（UAER＞200μg／min）、微量白蛋白尿（20～200μg／min）的NIDDM的血清LP（a）较正常白蛋白尿者（〈20μg／min）明显为高（P分别小于0．05和0．001）；而伴大量白蛋白尿者的Lp（a）也高于微量白蛋白尿者（P〈0．05）。UAER与血清Lp（a）明显正相关（r=0．23，p＜0．001），而与血糖、HbAlc无关。

Urinary albumin excreation rate(UAER) and Lp (a) were measured in 132 patients with non insulin-de-pendent diabetes mellitus in this study, The results showed: that Lp(a) in NIDDM with macroalbuminuria (UAER>200μg/min) or with microalbuminuria (20 ~ 200μg/min) was higher than with normoalbuminuria (<20μg/min ) (P<0.05, 0.001, respectively); Lp (a) level in NIDDM with macroalbuminuria is higher than with microalbuminuria (P<0.05). UAER is associated significantly with Lp(a) (r= 0. 23,P<0.001),not with serum glucose or HbAlc.