抗中性粒细胞胞浆抗体在肾小球疾病诊断中的应用

Significances of ANCA in diagnosing glomerulonephropathy

本文应用间接免疫荧光技术（IIF），检测45例正常人及84例各种肾小球疾病患者血清中的抗中性粒细胞胞浆抗体（ANCA），结果显示：新月体肾小球肾炎（GN）和坏死性GN组阳性率为66．7％（4／6），IgAGN阳性率为20％（3／15），其它GN阳性率为6．7％（1／15）。未分类肾炎组阳性率10．3％（4／39），SLE肾炎检出率为44．4％（4／9）。五组结果经卡方统计，阳性率存有明显差异（P＜0．005）。其中新月体GN和坏死性GN组和SLE肾炎组患者阳性率明显高于另外三组。因此认为ANCA在诊断和鉴别诊断有小血管炎表现的GN中有较高特异性和敏感性。

Using indirect immu no- fluoresce nce (IIF ), the Ant i- neutrophile cytoplasmic antibodies (ANCA) in serumsamples from 45 healthy controls and 84 subjects with glomerulonephritis were determined. The results showed that theANCA positive rate in the group of crescant glomerulonephritis and necrotic glomerulonephritis was 66. 7%,the OgAnephropathy was 20%. In other glomerulonephritis, the ANCA positive rates in unclassified. GN and SLE nephritiswere 6. 7%, 10. 3% and 44. 4%,respectively. The statistic results of five groups showed that the ANCA positive ratewas significantly different- Among them,the positive rate in crescent GN,necrotic GN and SLE nephritis were signifi-cantly higher than other groups. So it was considered that the detection of ANCA is specific and sensitive for diagnosistnd differencial diagnosis of glomerulonephritis with small angitis GN and multiples angitis GN.