ras基因联合血清APF水平与肝癌转移关系的研究

The Relationship Between ras Accompanying by Serum AFP Level and Metastasis of Hepatocellular Carcinoma

目的探讨ras基因及AFP水平与肝癌病程的关系。方法测定50例病理检查确诊的肝癌患者血清AFP水平,并检测其手术切除肝癌组织中ras的表达,分析ras基因及血清AFP联合检测与肝癌有无远处转移及术后复发的关系。结果(1)ras在肝癌组织中阳性表达率为64.0%,ras表达与肿瘤大小、有无肝内转移密切相关(P<0.05)。ras阳性、阴性表达病例3年复发率分别为65.6%、33.3%。(2)高血清AFP水平且ras阳性病例组3年复发率为76.2%,而低血清AFP且ras阳性病例组3年复发率45.5%,差异显著(P<0.05)。结论联合ras基因及血清AFP检测可作为判断肝癌术后复发的有效指标,多因素分析更有价值。

Objective To study the relationship between ras accompanying by serum AFP level and metastasis of hepatocenuar carcinoma. Methods ms protein expression and serum AFP level were examined in 50 patients with hepatocellular carcinoma. The relationships between ras, serum AFP level and metastasis rate, recurrence rate after hepatectomy were analysed. Results （ 1 ） Positive staining rate of ras in hepatocenular carcinoma was 64, 0%. The positive expression of ras correlated with tumor size ,intrahepatic metastasis and recurrence rate after hepatectomy（ P 〈 0. 05 ）. （2） The recurrence rate in high-serum AFP level group with positive was was 71.4%, while in hypo-serum AFP level was 36. 4% （ P 〈 0. 05 ）. Conclusion Protein expression of ras and serum AFP level are effective in dicators for recurrence and prognosis of hepatocenular carcinoma. The analysis of muhi-gene is more valuable than that of single.