摘要
AIM： To investigate the histopathological and geneticdifferences between polypoid growth （PG） and nonpolypoid growth （NPG） submucosal invasive colorectal carcinoma （CRC）.METHODS： A total of 96 cases of submucosal CRC were divided into two groups according to their growth type;60 cases of PG and 36 cases of NPG. The size, histological degree of dysplasia, depth of submucosal invasion and lymph node metastasis were compared between the two groups. Furthermore, expression of p53 was detected by immunohistochemical staining, and K-ras gene mutation was examined by polymerase chain reaction based single-strand conformation polymorphism （SSCP）.RESULTS： The average size of the lesions in the NPG group was significantly smaller than those in the PG group （7.5 mm vs 13.8 mm, P 〈 0.001）. The histological degree of dysplasia tended to be more severe in NPG group, while the incidence of submucosal massive invasion and the lymph node metastasis were both significantly higher in the NPG type than in the PG group （64.3% vs 43.3%, P = 0.004; 43% vs 7%, P =0.008, respectively）. In addition, K-ras gene mutations were detected in 67% of lesions in the PG group, but none in the NPG group, while no difference in p53immunohistochemical expression was found between the two groups.CONCLUSION： Compared with PG submucosal CRC,NPG type demonstrates more frequent submucosal massive invasion, more lymph node metastasis and a higher degree dysplasia. Genetically, NPG type shows much less frequent K-ras mutation.
瞄准：调查水虫息似的生长(PG ) 和非水虫息似的生长(NPG ) 之间的组织病理学说、基因的差别粘膜下层的侵略肤色表面的癌(CRC ) 。方法：粘膜下层 CRC 的 96 个案例的一个总数根据他们的生长类型被划分成二个组；PG 的 60 个案例和 NPG 的 36 个案例。尺寸，发育异常的组织学的度，粘膜下层侵略的深度和淋巴节点转移在二个组之间被比较。而且， p53 的表示被免疫检测组织化学的染色，并且 K 地岬基因变化被聚合酶链反应检验基于的单个海滨的符合构造多型性(SSCP ) 。结果：在 NPG 组的损害的平均尺寸是比在 PG 组的那些显著地小的(7.5 公里对 13.8 公里， P < 0.001 ) 。当粘膜下层的巨大的侵略和淋巴节点转移的发生比在 PG 组在 NPG 类型更高显著地是两个时，发育异常的组织学的度趋于在 NPG 组更严重(64.3% 对 43.3% ， P = 0.004；43% 对 7% ， P = 0.008，分别地) 。另外， K 地岬基因变化在 NPG 组在 PG 组，而是没有在 67% 损害被检测，当在组织化学的表示在二之间被发现的 p53 免疫的差别都不组织时。结论：与 PG 粘膜下层的 CRC 相比， NPG 类型表明更经常的粘膜下层的巨大的侵略，更多的淋巴节点转移和更高的度发育异常。遗传上， NPG 类型显示出更不经常的 K 地岬变化。
