银杏叶提取物对不稳定型心绞痛患者C-反应蛋白的影响

Treatment of unstable angina pectoris with extract of ginkgo biloba leaf (银杏叶) and its effect on C-reactive protein

目的:观察银杏叶提取物(EGB)治疗不稳定型心绞痛(UAP)及其对C-反应蛋白(CRP)的影响。方法:将100例UAP患者随机分为两组,每组50例。两组患者均同时给予肠溶阿司匹林片100 mg,每日1次;观察组给予EGB(舒血宁)20 ml、对照组给予硝酸甘油10 mg,均加入质量分数为5%的葡萄糖或质量分数为0.9%的生理盐水250 ml中静脉滴注,每日1次,疗程均为20 d。观察EGB治疗后的临床疗效及对收缩压、心率、心率收缩压乘积、血脂、血液流变学和血浆CRP的影响。结果:观察组患者心绞痛缓解及心电图改善总有效率分别为84%和90%,均明显优于对照组68%和64%(P均<0.05)。治疗后观察组心率收缩压乘积、血脂、血液流变学和血浆CRP含量明显减少,且与对照组相比差异均有显著性(P<0.05或P<0.01)。结论:EGB治疗不稳定型心绞痛疗效确切,同时减轻炎症反应,减少突发事件的发生,值得临床推广。

Objective： To observe the treatment of unstable angina pectoris （UAP） with extract of ginkgo biloba leaf （EGB, 银杏叶） and its effect on C- reactive protein （CRy）. Methods： One hundred patients with UAP were randomly divided into two groups （each n= 50）. All patients were given 100 mg aspirin enteric -coated tablets simultaneously once per day orally. Patients in observation group were given 20 ml of EGB （舒血宁）, and patients in the control group were given 10 mg of nitroglycerin. The drugs were added in 250 ml of either 5% glucose solution or 0. 9% normal saline for intravenous infusion once per day, and the treatment course was 20 days. The changes of clinical curative effect of EGB and its effect on systolic pressure, heart rate, cross product of heart rate and systolic pressure, blood lipids, hemorheology and plasma CRP were observed. Results： Patients in the observation group with alleviation of anginous symptoms and improvement in electrocardiogram （ECG） had total effective rates of 84% and 90% respectively, as compared to 68% and 64 % respectively in the＇control group （all P〈0. 05）. The cross product of heart rate and systolic pressure, blood lipids, hemorheology and plasma CRP in observation group were significantly lowered than those of control group （P〈0. 05 or P〈0.01）. Conclusion： EGB has clear therapeutic curative effect for UAP as well as concurrent reduction in the inflammatory response and decrease in the incidence of sudden events. It is recommended that the drug could be used more widely in clinics.