脂肪酸合成酶在膀胱移行细胞癌组织中的表达及其临床意义

Expression of fatty acid synthase in bladder transitional cell carcinoma and its significance

背景与目的:脂肪酸合成酶(fatty acid synthase,FAS)是一种新的肿瘤标志物,高表达常提示肿瘤的预后不良,由此本文旨在研究膀胱移行细胞癌中的表达及其临床意义。方法:对65例随访5年的膀胱移行细胞癌手术患者的石蜡标本进行FAS的免疫组织化学染色分析,并与15例正常膀胱粘膜组织进行对照。结果:与正常组织相比,FAS在膀胱移行细胞癌组织中高表达,阳性表达率58.5%(38/65),差异有显著性(P<0.05)。FAS的表达与肿瘤分级、初发、复发有关(P<0.05),但与临床分期及肿瘤数目无关。FAS阳性表达患者的5年生存率远低于阴性患者(18%vs.44%),差异有显著性(P<0.05)。结论:FAS在膀胱移行细胞癌组织中表达增高,酶活性增强;FAS在膀胱移行细胞癌组织中表达增高有提示不良预后的作用。

Background and purpose： Fatty acid synthase（FAS） is a new tumor marker, the high expression of which has been reported to be associated with poor prognosis of cancer patients. This study investigated the expression of FAS in transitional cell carcinoma （TCC） of bladder and its elinical significance. Methods： The expressions of FAS were detected by streptavidin-peroxidase innnonohistochemieal method in the paraffin embedded sections of 65 TCC patients and the clinical data had been reviewed. 15 normal bladder tissues were used as control group. Results： The positive rate of the expression of FAS in TCC was 58.5% （38/65）, while only 2 of 15 cases in control group expressed FAS protein. The difference was statistically significant, the expression of FAS was related to the histological grades and recurrence but not different pathological stages. Survival analysis revealed that the 5-yr survival rate was lower in FAS positive patients than in negative patients （ 18% vs. 44%, P 〈0.05）. Conclusions： Fatty acid synthase is ore,expressed in TCC of bladder and might serve as a biomarker tor the poor prognosis of the patients.