107例细支气管肺泡癌临床特征及预后分析

Clinical Characteristics and Prognostic Analysis of 107 Patients with Bronchioloalveolar Carcinoma

目的:分析探讨细支气管肺泡癌(BAC)的临床特点及预后因素。方法:对1990年1月～2000年12月于我院接受手术的107例细支气管肺泡癌的临床资料进行分析。结果:细支气管肺泡癌总体1年、3年及5年生存率分别为88.7%、64.8%和48.6%。单因素分析影响预后的因素为肿瘤直径(P=0.027)、支气管断端是否阳性(P=0.016)、TNM分期(P=0.000)、T分期(P=0.002)、N分期(P=0.000)、术后是否放疗(P=0.001);Cox回归多因素分析提示,TNM分期(P=0.000)和肿瘤直径(P=0.015)是独立的预后影响因素。结论:细支气管肺泡癌总体生存率优于其它非小细胞肺癌,影响其预后的因素主要为TNM分期和肿瘤直径。

Objective： To study the clinical characteristics and prognostic factors of bronchioloalveolar carcinoma. Methods： Clinical data of 107 inpatient cases seen in The Cancer Hospital of Tianjin Medical University, from 1990-2000, were retrospectively reviewed. Results： The overall 1- year survival rate was 88.7%, the 3-year survival rate was 64. 8%, and the 5-year survival rate was 48.6%. The main prognostic factors were tumor diameter （P=0.022）, bronchial stump （P=0.016）, TNM stage （P=0.000）, T stage （P=0.002）, N stage （P=0.000）, and postoperative radiotherapy （P=0.001）. Cox regression analysis suggests that TNM stage （P=0.000） and tumor diameter （P=0.015） are independent factors affecting prognosis. Conclusions： The overall survival rate of BAC was superior to other NSCLC. TNM stage and tumor diameter are independent factors affecting the prognosis of BAC.