终末期乙型肝炎肝移植后乙型肝炎病毒再感染的预防和治疗
被引量:2
摘要
全球进行原位肝移植(OLT)的患者中有5%~10%为HBV相关的慢性或暴发性肝病,而我国OLT患者多为HBV相关的终末期肝硬化或肝细胞癌。乙型肝炎(乙肝)患者OLT的预后在很大程度上取决于移植肝再感染的预防。在无任何防治措施的情况下,移植后HBV再感染率超过80%,这与原发性肝病的严重程度及移植时HBV的复制有关。再感染引起的急、慢性肝病可导致移植肝肝功能衰竭、患者死亡或需要再次进行肝移植。
出处
《中华传染病杂志》
CAS
CSCD
北大核心
2007年第3期185-188,共4页
Chinese Journal of Infectious Diseases
参考文献21
-
1Steinmuller T, Seehofer D, Rayes N, et al. Increasing applicability of liver transplantation for patients with hepatitis B-related liver disease. Hepatology, 2002, 35 : 1528-1535.
-
2Bock CT, Tillmann HI., Torresi J, et al. Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation. Gastroenterology, 2002, 122:264-273.
-
3Villeneuve JP, Condreay LD, Willems B, et al. Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B. Hepatology, 2000,31 : 207-210.
-
4Perrillo RP, Wright T, Rakela J, et al. A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B. Hepatology, 2001, 33:424-432.
-
5Rosenau J, Bahr MJ, Tillmann HL, et al. Lamivudine and low-dose hepatitis B immune globulin for prophylaxis of hepatitis B reinfection after liver transplantation possible role of mutations in the YMDD motif prior to transplantation as a risk factor for reinfection. J Hepatol, 2001, 34:895-902.
-
6Fontana RJ, Keeffe EB, Carey W, et al. Effect of lamivudine treatment on survival of 309 North American patients awaiting liver transplantation for chronic hepatitis B. Liver Transpl,2002, 8:433-439.
-
7Schiff ER, I-ai CL, Hadziyannis S, et al. Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre-and post-liver transplantation patients. Hepatology, 2003, 38 : 1419-1427
-
8Shakil AO, Angus P, Gerken G, et al. Entecavir reduces viral load in liver transplant patients who have failed prophylaxis or treatment for hepatitisB. Hepatology, 2001, 34:619A.
-
9Schreibman IR, Schiff ER. Prevention and treatment of recurrent hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues. Ann Clin Microbiol Antimicrob, 2006, 5:8-15
-
10Peters MG, Hann Hw H, Martin P, et al. Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B. Gastroenterology,2004, 126:91-101.
二级参考文献16
-
1Todo S, Demetris A J, Van Thiel D, et al. Orthotopie liver transplantation for patients with hepatitis B virus-related liver disease. Hepatology, 1991, 13 : 619-626.
-
2O'Grady JG, Smith HM, Davies SE, et al. Hepatitis B virus reinfection after orthotopic liver transplantation, serological and clinical implications. J Hepatol, 1992, 14 : 104-111.
-
3Samuel D, Muller R, Alexander G, et al. Liver transplantation in European patients with the hepatitis B surface antigen. N Engl J Med, 1993, 329 : 1842-1847.
-
4Brunetto P, Ciccorossi F, Filipponi A, et al. Recurrence of hepatitis B after liver transplantation is associated with intrahepatic HbcAg and serum IgM anti-HBs. J Hepatol, 2001, 34(Suppl 1) : 42.
-
5Perfillo R, Schiff E, Yoshida E, et al. Adefovir dipivoxil for the treatment of lamivudine-resistent hepatitis B mutants. Hepatology,2000, 32: 129-134.
-
6Lo CM, Fan ST, Liu CL, et al. Prophylaxis and treatment of recurrent hepatitis B after liver transplantation. Transplantation, 2003,75 ( 3 Suppl) : 41-44.
-
7Karasu Z, Ozacar T, Akyildiz M, et al. Low-dose hepatitis B immune globulin and higher-dose lamivudine combination to prevent hepatitis B virus recurrence after liver transplantation[J]. Antivir Ther, 2004,9(6):921-927.
-
8Ali H, Egawa H, Uryuhara K, et al. Prevention of hepatitis B virus recurrence after living donor liver transplantation [J]. Transplant Proc, 2004,36(9):2764-2767.
-
9Saab S, Chang AJ, Comulada S, et al. Outcomes of hepatitis C- and hepatitis B core antibody-positive grafts in orthotopic liver transplantation[J]. Liver Transpl, 2003,9(10):1053-1061.
-
10Terrault NA, Vyas G. Hepatitis B immune globulin preparations and use in liver transplantation[J]. Clin Liver Dis, 2003,7(3):537-550.
共引文献15
-
1蔡常洁,李敏如.肝癌肝移植术后并发症的防治[J].肝胆外科杂志,2006,14(2):83-84. 被引量:2
-
2牛玉坚,臧运金,陈新国,李威,朱晓丹,刘煜,韦中余,张忠涛,王宇,沈中阳.肝移植中乙型肝炎免疫球蛋白不同给予方式及静脉负荷量的研究[J].中华外科杂志,2006,44(21):1444-1447. 被引量:2
-
3黄松平,蔡卫华,凌勇武,吴月平.拉米夫定联合小剂量乙肝免疫球蛋白防止肝移植术后HBV感染的疗效分析[J].实用肝脏病杂志,2006,9(6):361-363. 被引量:1
-
4牛玉坚.乙型肝炎免疫球蛋白在预防肝移植后乙型肝炎复发中的作用[J].中华器官移植杂志,2006,27(12):763-764. 被引量:8
-
5魏宪义,贾继东,栾荣生.拉米夫定联合乙肝免疫球蛋白防治肝移植术后乙肝复发的多中心临床研究[J].肝胆外科杂志,2006,14(6):435-440. 被引量:6
-
6黄松平,蔡卫华,凌勇武,吴月平,韩旭东.乙型肝炎相关肝病肝移植患者HBV复发因素临床分析[J].交通医学,2006,20(6):724-725.
-
7牛玉坚,臧运金,陈新国,韦中余,张忠涛,王宇,沈中阳.肝移植患者采取不同的方法应用乙型肝炎免疫球蛋白的随机和对照研究[J].中华器官移植杂志,2007,28(6):359-361. 被引量:1
-
8李健,魏宪义,傅志仁.拉米呋啶、乙肝免疫球蛋白防治肝移植术后HBV再感染的功效比较及临床应用进展[J].中华肝胆外科杂志,2007,13(8):568-570. 被引量:3
-
9孙丽莹,沈中阳,朱志军,饶伟,张雅敏,孙晓叶,曾志贵,曲伟,薛芳箐.肝移植术后乙型肝炎复发的回顾性分析[J].外科理论与实践,2008,13(4):326-329. 被引量:7
-
10魏宪义,蒋德席,栾荣生,严律南,贾继东,韩婷.182例肝移植病人术后19个月乙肝复发的临床随访观察[J].中华肝胆外科杂志,2008,14(10):676-679. 被引量:2
同被引文献28
-
1江淑爱.早产儿基因重组乙肝疫苗不同接种程序的免疫应答研究[J].临床儿科杂志,2005,23(7):450-451. 被引量:18
-
2徐相蕊.儿童群发性癔症误诊为乙肝疫苗反应18例分析[J].中国误诊学杂志,2005,5(9):1727-1728. 被引量:5
-
3胡桂英,谭文华,马金赏,张景权,康志海.妊娠后期接种乙肝疫苗免疫效果的观察[J].实用妇产科杂志,1995,11(6):310-311. 被引量:37
-
4朱启镕.乙肝病毒母婴传播产前阻断的研究进展[J].中华妇幼临床医学杂志(电子版),2006,2(1):48-49. 被引量:4
-
5庄贵华,颜虹,王学良.乙型肝炎疫苗接种无应答原因与机制[J].中华肝脏病杂志,2006,14(2):157-160. 被引量:27
-
6吴国豪.肝移植病人的营养支持[J].中华普通外科杂志,2007,22(8):640-640. 被引量:1
-
7Gregory A D,Robert M,Jacobson Jn.Prevention of hepatitis B with the hepatitis B vaccine[J].New Eng J Med,2005,352(7):740.
-
8Gregory A D,Rorbt M,Jacobson Jn.Prevention of Hepatitis B with the hepatitis B Vaccine[J].New Eng J Med,2004,351(27):2832-2837.
-
9Roul J,David,Safety and immunogenicity of a new mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens in adults[J].Israel Med Association J,2001,3(5):328-332.
-
10Weussman S,Feucht C,Moore BA,et al.Response to hepatitis B vaccine in HIV postive patients[J].J Viral Hepat,2006,13(2):81-86.
引证文献2
-
1朱科伦,朱郇悯,曾文铤,梁建新,张为民.主被动免疫预防乙肝的研究进展[J].广州医药,2007,38(5):3-6. 被引量:1
-
2李霄,陶开山,岳树强,王德盛,窦科峰.腺苷蛋氨酸对肝移植术后受体早期肝功能恢复的影响[J].中华普通外科杂志,2013,28(10):770-773. 被引量:1
-
1虞磊,李建平,金慧涵,胡明华,竺来法,戴途.肝移植后乙型肝炎病毒再感染的防治[J].齐齐哈尔医学院学报,2004,25(10):1138-1138.
-
2张同琳.肝移植术后乙型肝炎病毒再感染的防治[J].中华肝脏病杂志,2004,12(6):373-373. 被引量:3
-
3朱建平,张同琳,袁炯,宋世兵,修典荣,付卫,王德臣,蒋斌,马朝来,候宽永,庄辉.肝移植术后乙型肝炎病毒再感染的防治[J].中华器官移植杂志,2003,24(2):78-79. 被引量:7
-
4王永刚,王宇明.肝移植后乙型肝炎病毒再感染相关因素的研究进展[J].世界华人消化杂志,2003,11(9):1460-1464. 被引量:5
-
5张海斌,李团结,杨宁,朱楠,司马辉,卢军华,杨广顺.肝移植术后乙型肝炎病毒再感染的防治[J].中国普通外科杂志,2008,17(7):633-635.
-
6郑树森,吴健,王伟林,黄东胜,梁廷波,卢安卫.拉米夫定预防肝移植术后乙型肝炎病毒再感染的作用[J].中华医学杂志,2002,82(7):445-448. 被引量:15
-
7史宪杰,周宁新,纪文斌,段伟东,杨滔,苏茂生,余强,张煊.肝移植术后乙型肝炎病毒再感染的预防[J].中华医院感染学杂志,2007,17(5):527-529. 被引量:6
-
8傅海龙,傅志仁.肝移植术后乙型肝炎复发的原因及防治[J].第二军医大学学报,2004,25(8):882-885. 被引量:2
-
9傅海龙,傅志仁.预防肝移植术后乙型肝炎复发的研究进展(文献综述)[J].国外医学(外科学分册),2003,30(5):282-285. 被引量:1
-
10郭瑾.RTE弹性特征量无创评估乙型肝炎肝纤维化程度的可行性研究[J].肝脏,2014,19(8):617-618.