摘要
以红色素基因全长cDNA作探针,对20例正常人,26例双相型情感性精神病患者进行限制性片段长度多态性(RFLP)分析,SacI在部分正常人和部分患者中产生7.5kb、4.8kb和4.5kb,呈多态性改变的片段。正常人具多态改变的占45%,患者为46.2%。按X染色体数计,正常人出现7.5kb限制性片段的频率为14.3%,患者为32.4%。
Using the cloned full length red pigment cDNA (HS7) as a probe,we analysed 20 normal individuals and 26 affective disorder(AD) patients,and found polymorphisms in part AD and normal individuals.The polymorphic fragments of SacI were 7.5kb,4.8kb and 4.5kb,respectively.45% in the normal individuals and 46.2% in the AD patients showed polymorphisms.According to the numbers of the chromosome X,the frequency of the 7.5kb fragment in the normal individuals was 14.3% ,while 32.4% in AD,but these two frequencies are not significantly different(χ 2=2.13,df=1,P>0.05).
出处
《哈尔滨医科大学学报》
CAS
1997年第1期1-3,共3页
Journal of Harbin Medical University
基金
国家自然科学基金
关键词
红色素基因
RFLP
情感性精神病
Red pigment gene
Restriction fragment length polymorphisms
Affective disorder
Linkage