摘要
采用数字化冠脉造影图像,测量由内皮依赖性扩张物质(substanceP,物质P)引起的冠脉直径变化,评价血管内皮功能。35例受试者,9例冠脉造影正常者为对照组,26例冠脉造影明显改变者为冠心病组。受试者在行诊断性冠脉造影术后,先、后分别在冠状动脉内注入生理盐水和物质P(25pmol/min),每次注入前、后的造影结果,通过计算机数字化图像分析系统测量冠状动脉直径变化。结果显示,物质P对正常的冠状动脉有明显的扩张作用,而动脉粥样硬化病变的血管对物质P的反应明显减弱。提示,冠脉造影有病变的患者。
Endothelial dysfunction is closely linked to the development of atherosclerosis and play an integral part in patients with coronary artery disease.To assess coronary endothelial function in vivo,segmental responses of coronary arteries to endothelium-dependent vasodilator substance P were examined in 9 patients with normal angiograph and in 26 patients with diseased coronary arteries using a quantitative angiographic technique.Coronary artery responses to substance P was highly significant between normal and diseased coronary ateries.It would appear a severe impairment of endothelial function in diseased coronary arteries.
出处
《哈尔滨医科大学学报》
CAS
1997年第1期24-26,共3页
Journal of Harbin Medical University
关键词
血管造影术
内皮功能
冠状动脉
Quantitative angiography
Endothelial function
Coronary artery