COX-2在子宫腺肌病患者子宫内膜和肌组织中的表达及意义

Expression and significance of COX-2 in endometrium and muscle layer of adenomyosis

目的观察环氧合酶-2(COX-2)在子宫腺肌病患者子宫内膜和肌组织中的表达,探讨其意义。方法以64例手术切除子宫患者为研究对象,其中子宫腺肌病34例为观察组,子宫肌瘤30例为对照组。采用免疫组织化学方法检测COX-2在两组子宫内膜和肌组织中的表达。结果观察组增殖期和分泌期在位内膜及异位内膜COX-2阳性率均高于对照组,异位内膜高于在位内膜,P均<0.01;异位内膜病灶周围肌层COX-2阳性率显著高于正常子宫肌层(P<0.05);异位内膜增殖期和分泌期COX-2免疫组化评分均显著高于在位内膜,P<0.01。结论COX-2高表达可能与子宫腺肌病的发生、发展有关。

[Objective] To investigate the expression of COX-2 in endometrium and muscle layer of adenomyosis patients, approach its significance. [Methods] 64 patients excised uteruses were enrolled, 34 adenomyosis patients were in study group and 30 uterus myoma patients were in control group. Immunohistochemistry was used to mensurate COX-2 expression in endometrium and uterus muscle layer of two groups. [Results] In proliferative phase and secretive phase,the expression rate of COX-2 in both ectopic endometriurn and eutopic endometrium in study group were higher than those in control group,the rate in ectopic endometrium was higher than that in eutopic endometrium（P〈：0. 01） ; the expression rate of COX-2 in muscle layer group around adenomyosis focus was 76. 47%,and the expression of COX-2 in normal muscle layer of uterus was negative. The histology score of the expression of COX-2 in ectopic endometrium of proliferative phase was 8. 71±1.43,and the score of secretive phase was 9. 30± 1.22; the score in eutopic endometrium of proliferative phase was 4. 55± 0. 92,and the score of secretive phase was 4.84±1.16. The differences between the two groups were significant （P〈0.01）. [Conclusions] There is a high expression of COX-2 in adenomyosis ectopic endometrium, eutopic endometrium and muscle layer around focus, it may be concerned with the genesis and development of adenomyosis.