摘要
研究了小鼠ｉｇ不同酸度溶液和活性碳对地西泮肠胃循环的干扰，是否影响其中枢抑制作用。ＨＰＬＣ法测定证实，酸性液体（ｐＨ１）ｉｇ可使小鼠ｉｖ地西泮后１ｈ胃中地西泮排泌量显著增加。以ｉｖ地西泮后睡眠持续时间、自主活动抑制及转棒试验跌落率的恢复速度和死亡率为指标，比较了酸性活性碳（２ｇ·ｋｇ－１）、中性活性碳和生理盐水对地西泮中枢抑制作用的影响。结果表明，酸性碳组动物其地西泮所致中枢抑制状态的恢复速度明显加快，死亡率降低。
The present study was designed to examine whether disturbance of the enterogastric circulation of diazepam would obviously affect its inhibitory action on CNS. Intragastric administration of acidic liquid (pH 1) elicited a marked increase in the amount of diazepam in the gastric juice of mice 1 h after iv diazepam, as measured by HPLC method. The effects of ig acidic charcoal (2 g·kg -1 , pH 1), neutral charcoal and normal saline on diazeapm induced CNS depression were compared by studying the duration of hypnotic action, inhibition of spontaneous activity, dropping rate in rotating rod test and mortality after iv diazepam (10～40 mg·kg -1 ) in mice. The results showed that the animals receiving ig acidic charcoal recovered more rapidly from CNS depression and exhibited lower mortality than the animals in neutral charcol group and normal saline group.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第2期90-93,共4页
Acta Pharmaceutica Sinica
基金
安徽省教委自然科学研究课题
关键词
地西泮
肠胃循环
中枢抑制作用
安定
Diazepam
Enterogastric circulation
Active charcoal
CNS depression
