防治成人呼吸窘迫综合征的人工重组肺泡表面活性剂研制II.生物发光法筛选制剂处方

ARTIFICIAL RECONSTITUTED PULMONARY SURFACTANT USED FOR PREVENTION AND TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME II. BIOLUMINESCENCE METHOD FOR OPTIMIZING FORMULATION

在前期用表面化学方法进行防治成人呼吸窘迫综合征的药物制剂处方筛选基础上，通过建立尘肺动物模型，用生物发光技术从清除自由基能力角度对制剂进行处方筛选，获到了有良好表面性能和一定自由基清除能力的人工重组肺泡表面活性剂制剂处方。该制剂有待经模型动物防治试验评价。

Based on optimizing the formulations of artificial reconstituted pulmonary surfactant (APS) used for the prevention and treatment of adult respiratory distress syndrome (ARDS) by a surface chemical method, a quartz lung animal model to obtain active alveolar macrophages (AMs) was established, using a bioluminesence technique to optimize APS’s formulation according to the free radical scavenging abilities of APS. An optimal formulation was obtained, which showed good surface properties and free radical scavenging abilities. The APS preparation will be used in ARDS animal model test.