氯硝西泮抗惊厥作用耐受及停药后大鼠脑内NMDA受体放射自显影观察

AUTORADIOGRAPHY OF NMDA RECEPTORS IN AMYGDALA KINDLED RATS WITH TOLERANCE TO AND DEPENDENCE ON THE ANTICONVULSANT EFFECT OF CLONAZEPAM

氯硝西泮抗惊厥作用耐受及停药后大鼠脑内ＮＭＤＡ受体放射自显影观察廖建湘王丽左启华（北京医科大学第一医院儿科１０００３４）氯硝西泮是一种常用的抗癫痫药，但容易诱发耐受，而耐受后撤药又会导致撤药症状，从而限制其应用［１］。癫痫点燃动物模型脑组织及手术获...

Mechanisms underlying tolerance to and dependence on the anticonvulsant effect of clonazepam are not clear. Autoradiography of the NMDA receptors in amygdala kindled rats with tolerance to and dependence on the anticonvulsant effect of clonazepam was carried out. When tolerance developed, the binding of TCP ( N (1 thieny)cyclohexylpiperidine) to NMDA receptors was found to be increased at the polymorphocellular layer of the right CA 1, and decreased at the molecular layer of the cerebellar ansiform lobule. On day 7 of the discontinuation of clonazepam, the binding did not change further. These changes may be responsible for the tolerance to and dependence on the anticonvulsant effect of clonazepam. However, the exact significance of these results should be further investigated.