1The IONA Study Group.Trial to show the impact of nicorandil in angina (IONA):design,methodology,and management.Heart,2001;85 (6):E9
2The IONA Study Group.Effect of nicorandil on coronary events in patients with stable angina:the Impact Of Nicorandil in Angina (IONA) randomised trial.Lancet,2002; 359 (9314):1269 ～ 1275
3Frampton J,Buckley MM,Fitton A.Nicorandil:a review of its pharmacology and therapeutic efficacy in angina pectoris.Drugs,1992; 44 (4):625 ～ 655
4Markham A,Plosker GL,Goa KL.Nicorandil:an updated review of its use in ischaemic heart disease with emphasis on its cardioprotective effects.Drugs,2000; 60 (4):955 ～ 974
5Patel DJ,Purcell HJ,Fox KM.Cardioprotection by opening of the KATP channel in unstable angina:is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil.Eur Heart J,1999; 20:51 ～ 57
7Lee TM,Su SF,Chou TF,et al.Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty.Circulation,2002; 105 (3):334 ～ 340
8Sakai K,Yamagata T,Teragawa H,et al.Nicorandil enhances myocardial tolerance to ischemia without progressive collateral recruitment during coronary angioplasty.Circ J,2002; 66 (4):317 ～ 322
9Matsuo H,Watanabe S,Segawa T,et al.Evidence of pharmacologic preconditioning during PTCA by intravenous pretreatment with ATPsensitive K+ channel opener nicorandil.Eur Heart J,2003; 24 (14):1296 ～ 303
10Ashikaga T,Nishizaki M,Arita M,et al.Opening of KATP channel attenuates the increase in QT dispersion produced by the first balloon inflation during coronary angioplasty.Circ J,2002; 66 (5):469 ～ 472
