MMP-2、MMP-9在胃肠道间质瘤中的表达及其临床意义

Clinical significance of MMP-2、MMP-9 expression in gastrointestinal stromal tumor

目的:探讨基质金属蛋白酶(MMP)-2、MMP-9在胃肠道间质瘤(GIST)中的表达及其与预后的关系。方法:采用免疫组化方法检测54例GIST组织中的MMP-2、MMP-9的表达,分析与各病理参数的关系。结果:肿瘤组织中的MMP-2、MMP-9阳性率分别为85.2%、83.3%,并随着GIST恶性程度的增高,其表达均出现递增趋势,差异有显著性意义(P<0.05);与肿瘤良恶性、生长方式、肿瘤大小、肿瘤中心有无坏死亦有明显关系(P<0.01)。单因素分析MMP-2、MMP-9阳性表达的患者有较高的5年生存率,多因素分析发现MMP-2、MMP-9共表达能独立预测患者的5年生存率。结论:MMP-2、MMP-9在GIST中的表达率可以作为判断GIST性质、恶性程度、转移及预后的客观指标。

Objectives： To evaluate the clinical significance of MMP-2, MMP-9 expression in gastrointestinal stromal tumor. Methods： 54 of GIST were studied for MMP-2, MMP-9 by immunohistochemical staining, and the relationship of MMP-2, MMP-9 with each pathological factor were analyzed. Results：The positive expression of MMP-2, MMP-9 was 85.2% （46/54）, 83.3% （43/54） respectively. The expression of MMP-2, MMP-9 increased significantly according to the malignant increasing （P〈0.01） and associated with pattern of tumor growing, tumor size, and centre necrosis （P〈0,01）. In univariate analysis, MMP-2, MMP-9 were significantly associated with tumorfree survival. In multi-variate analysis, co-expression of MMP-2 and MMP-9 was unfavorablely related with tumor free survival （RR=2.487： P〈0.05）. Conclusion： Over-expression of MMP-2 and MMP-9 in GIST judge the malignant degree and predicting the prognosis of patients with GIST.