丁胺卡那、左氧氟沙星治疗耐多药肺结核临床观察

The clinical observation on the effects of levofloxacin and amikacin on the treatment of patients with multi-drug resistant pulmonary tuberculosis

目的观察丁胺卡那,左氧氟沙星在耐多药肺结核(MDR-TB)治疗中的疗效。方法68例耐多药肺结核患者随机分为治疗组36例和对照组32例。治疗组采用3DZThVA/15DThV,对照组采用3DZThES/15DThE方案治疗。结果疗程结束后,治疗组痰菌阴转率,病灶吸收好转率分别为86.11%,88.39%,而对照组分别为59.38%,59.38%,两组比较,差异有显著性。结论对耐多药肺结核采用含丁胺卡那、左氧氟沙星的方案治疗MDR-TB效果肯定。

Objective To observe the effects of levofloxacin and amikacin on multi-drug resistant pulmonary tuberculosis（MDR- TB）. Methods 68 cases with MDR-TB were randomly divided into experimental group （n =36） and control group （n =32）. Experimental group was treated with 3DZThVA/15DThV, control group was treated with 3DZThES/15DThE. Result When the course was completed, the sputum negative conversion rate and the radiographic resolution rate in the experimental group were 86.11% ,88.36%, which were higher than the control 59.38% and 59.38%. Conclusion The treatment scheme of combine levofloxacin and amikacine was appropriate to apply on MDR-TB.