血胱抑素C在腹泻病患儿肾功能损害中的价值

Evaluation of Serum Cystatin C in Renal Impairment of Infantile Diarrhea

目的探讨血胱抑素C(CysC)水平对小儿腹泻患者肾功能损害的价值。方法根据诊断标准将入选的>1岁的腹泻病患儿并分为轻型、中型和重型腹泻3组,检测血清CysC、尿素(Urea)、血清肌酐(Scr)水平及尿常规相关项目,与健康对照组进行比较,并对其敏感性进行分析。结果重型与中型腹泻组血清CysC高于轻型腹泻组及健康对照组,具有显著性差异(Pa<0.01);其阳性检出率CysC>Urea>尿常规>Scr,CysC明显优于其他项目。结论CysC为小儿腹泻肾功能损害的敏感指标,其敏感性优于Urea、Scr,且与腹泻病情严重程度密切相关。

Objective To explore the value of cystatin C（ Cys C） level to the renal function impairment of infantile diarrhea. Methods The selected infantile diarrhea sufferers more than 1 year old were divided into light, middle and severe groups according to the diagnosis standa- rds and their Cys C, urea, serum creatinine （Scr） consistency and urine routine together with its significant related items were detected and compared with the normal references, and their sensitivity analysis was performed. Results The levels of Cys C in severe and middle crews were definitely higher than these in light and normal groups, and the differences were together with its significance（Pa 〈 0.01 ） and the positive detection rate presented as follows ：Gys C 〉 urea 〉 urine routine 〉 Scr;and in this detection, Cys C had an obvious advantage to other items, and the positive detection rate presnted as follows： Cys C 〉 urea 〉 urine routine 〉 Scr; and in this detection, Cys C had an obvious advantage to other items. Conclusions Cyc C is considered as one sensitive index of renal function impairment of infantile diarrhea sufferer;its sensitivity is advanced than Urea, Scr, and also is closely correlated with the state of diarrhea.