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2型糖尿病患者罗格列酮治疗前后血浆胃促生长素水平的变化及其与胰岛素抵抗的关系 被引量：9

Change in plasma ghrelin level and the relation between ghrelin and insulin resistance in type 2 diabetic patients after rosiglitazone therapy
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摘要 探讨2型糖尿病在应用磺酰脲类药物治疗的基础上加用罗格列酮类药物治疗前后血浆胃促生长素水平变化及其与胰岛素抵抗的关系。2型糖尿病患者应用罗格列酮治疗4周及12周血浆胃促生长素水平升高,胰岛素抵抗指数降低。 The change in plasma ghrelin level after 4- and 12-week adjunctive therapy of rosiglitazones in type 2 diabetic patients inadequately controlled by sulphonylurea alone was observed and the relation between ghrelin and insulin resistance was analysed. The results showed that rosiglitazones significantly increased circulating ghrelin level and obviously decreased insulin resistance index after therapy for 4 and 12 weeks in type 2 diabetic patients.
作者 高燕明 卢桂芝 蒋秋明 董爱梅 郭晓蕙 高妍 庞永正 唐朝枢
机构地区 北京大学第一医院内分泌科 北京大学第一医院心血管研究所
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第2期149-150,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 糖尿病 2型 胃促生长素 罗格列酮 Diabetes mellitus,type 2 Ghrelin Rosiglitazone
分类号 R587.1 [医药卫生—内分泌]
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参考文献8

  • 1邵莉,李荣英,张一波,赵双霞,乔洁,朱鋐达,陈名道.不同饥饿时段对常规及高脂饮食大鼠胃壁组织胃促生长素(ghrelin)表达的影响[J].中华内分泌代谢杂志,2005,21(3):265-268. 被引量：7
  • 2Poykko SM, Kellokoskl E, Horkko S, et al. Low plasma ghrelln is assosiatied with insulin resistance, hypertension and the prevalence of type 2 diabetes. Diabetes, 2003,52:2546-2553.
  • 3Katsukl A, Urakawa H, Gabazza EC, et al. Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsullnemia and insulin resistance in patients with type 2 diabetes mellitus. Eur J Endocrinol, 2004,151:573-577.
  • 4高燕明,卢桂芝,董爱梅,陈宇,杨建梅,蔡大勇,庞永正,唐朝枢.2型糖尿病和糖调节受损患者在葡萄糖负荷时血浆Ghrelin水平的变化及其与胰岛素的关系[J].中华糖尿病杂志（1006-6187）,2004,12(5):352-355. 被引量：2
  • 5Christof S, Rudger H, Thilo S, et al. Circulating ghrelin levels in the patients with polycystic ovary syndrome. J Clin Endoerinol Metab, 2002, 87:4007-4010.
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二级参考文献20

  • 1Cappiello Ⅴ, Ronchi C, Morpurgo PS, et al. Circulating Ghrelin levels in basal conditions and during glucose to1erance test in acromegalic patients. Eur J Endocrinol, 2002,147:189-194.
  • 2Shiiya T, Nakazato M, Mizuta M,et al. Plasma Ghrelin levels in lean and obese humans and the effect of glucose on Ghrelin secretion. J Clin Endocrinol Metab, 2002,87 : 240-244.
  • 3Haqq AM, Farooqi IS, O'Rahilly S, et al. Serum Ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in prader-willi syndrome. J Clin Endocrinol Metab, 2003, 88: 174-178
  • 4Date Y, Nakazato M, Hashiguchi S,et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002,51:124-129.
  • 5Egido EM, Rodriguez-Gallardo J, Silvestre RA, et al. Inhibitory effect of Ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol, 2002,146: 241-244.
  • 6Anderwald C, Brabant G, Bernroider E,et al. Insulin-dependent modulation of plasma Ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients. Diabetes, 2003,52:1792-1798.
  • 7Schofl C, Horn R, Schill T,et al. Circulating Ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab, 2002,87 : 4607-4610.
  • 8Makino Y, Hosoda H, Shibata K, et al. Alteration of plasma Ghrelin levels associated with the blood pressure in pregnancy.Hypertension, 2002,39: 781-784.
  • 9Poykko S, Ukkola O, Kauma H, et la. Ghrelin Arg 51 Gln mutation is a risk factor for type 2 diabetes and hypertension in a random sample of middle-aged subjects. Diabetologia, 2003,46:455-458.
  • 10Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 1999,402:656-660.

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中华内分泌代谢杂志
2007年 第2期

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