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高尿酸血症血尿酸与TNF-α、IL-6的关系 被引量：16

Association of blood uric acid with TNF-αand IL-6 in patients with hyperuricemia
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摘要 测定高尿酸血症及其合并糖脂代谢紊乱患者血清肿瘤坏死因子α(TNF-α)与白细胞介素6 (IL-6)水平,结果显示高尿酸血症患者TNF-α、IL-6水平明显高于正常对照者(均P<0.01),高尿酸血症并发糖脂代谢紊乱时血清TNF-α、IL-6水平升高更为显著。 Serum tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） levels were measured in patients with simple hyperuricemia or hyperlipidemia combined with hyperglycemia and hyperuricemia. The results showed that TNF-α, IL-6 levels in patients with hyperuricemia were higher than those in normal controls （ both P 〈 0.01 ） , and even higher in patients with hyperuricemia combined with hyperlipidemia and hyperglycemia.
作者 路巍 王颜刚 阎胜利 宋达琳
机构地区 青岛大学医学院附属医院内分泌科 青岛市市立医院内分泌科 青岛市市立医院心内科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第2期160-161,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 高尿酸血症 肿瘤坏死因子Α 白细胞介素6 Hyperuricemia Tumor necrosis factor-α Interleukin-6
分类号 R589.7 [医药卫生—内分泌]
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参考文献8

  • 1苗志敏,赵世华,王颜刚,李长贵,王忠超,陈颖,陈新焰,阎胜利.山东沿海居民高尿酸血症及痛风的流行病学调查[J].中华内分泌代谢杂志,2006,22(5):421-425. 被引量：206
  • 2Vazquez-Mellado J, Alvarez Hemandez E, Burgos-Vargas R. Primary prevention in rheumatology : the importance of hyperurlcemla. Best Pract Res Clin Rheumatol, 2004,18 : 111-124.
  • 3Kern PA, Saghizadeh M, Ong JM, et al. The expression of tumor necrosis factor in human adipose tissue. J Clin Invest, 1995,95:2111- 2119.
  • 4Tsunoda S, Kamide K, Minami J, et al. Decreases in serum uric acid by melioration of insulin resistence in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. Am J Hypertens, 2002,15:697-701.
  • 5Hotamisligil GS. The role of TNF-α and TNF receptors in obesity and insulin resistance. Trends Endocrinol Metab, 2000,11:212-217.
  • 6Suzuki D, Miyazaki M, Naka R, et al. In situ hybridization of interleukin 6 in diabetic nephropathy. Diabetes, 1995,44:1233-1238.
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二级参考文献13

  • 1苏工,米树华,陶红,王南晔,郑虹.代谢综合征患者血尿酸水平与冠心病的关系[J].中华内分泌代谢杂志,2005,21(1):66-67. 被引量：23
  • 2李春霖,田慧,潘长玉,陆菊明.老年糖耐量受损人群合并代谢异常及其转归分析[J].中华内分泌代谢杂志,2005,21(3):230-232. 被引量：16
  • 3毛玉山,周丽诺,叶红英,黄童,陈长喜,杜娟,洪中立,胡仁明.宁波市某石化企业员工高尿酸血症和痛风患病率调查[J].中华内分泌代谢杂志,2006,22(4):338-341. 被引量：40
  • 4Levy D,Kannel WB,Vasan RS,et al.Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence.Hypertension,2005,45:28-33.
  • 5Iseki K,Ikemiya Y,Inoue T,et al.Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort.Am J Kidney Dis,2004,44:642 -650.
  • 6Kramer HM,Curhan G.The association between gout and nephrolithiasis:The National Health and Nutrition Examination Survey,1988-1994.Am J Kidney Dis,2002,40:37-42.
  • 7Tsai EC,Boyko EJ,Leonetti DL,et al.Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men.Int J Obes Relat Metab Disord,2000,24:485-491.
  • 8Denzer C,Muche R,Mayer H,et al.Serum uric acid levels in obese children and adolescents:linkage to testosterone levels and premetabolic syndrome.J Pediatr Endocrinol Metab,2003,16:1225-1232.
  • 9Choi HK,Liu S,Curhan G.Intake of purine-rich foods,protein,and dairy products and relationship to serum levels of uric acid:the Third National Health and Nutrition Examination Survey.Arthritis Rheum,2005,52:283-289.
  • 10Nakanishi N,Okamoto M,Yoshida H,et al.Serum uric acid and for development of hypertension and impaired fasting glucose or type 2 diabetes in Japanese male office workers.Euro J Epidemiol,2003,18:523-530.

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中华内分泌代谢杂志
2007年 第2期

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