肾上腺髓质素与糖尿病肾病小管间质病变的关系

Relationship between adrenomedullin and diabetic tubulointerstitial injury

42例糖尿病患者分为单纯糖尿病组,早期糖尿病肾病(DN)组,临床期DN组;另设对照组10例;检测其血浆肾上腺髓质素(ADM)、尿α_1微球蛋白(MG)及β_2-MG的水平。结果提示与对照组相比,血浆ADM水平随DN进展而逐渐上升;血ADM与小管间质损伤标志物尿α_1-MG、β_2-MG水平呈正相关(均P<0.05),提示ADM在小管间质病变的发展中可能起着重要的作用。

Forty-two patients with type 2 diabetes mellitus （DM） were refered to 3 groups： type 2 DM without diabetic nephropathy （DN）, type 2 DM with DN in the initial stage and type 2 DM with DN in the clinical stage. Ten healthy subjects were served as control group. Plasma adrenomedullin （ADM）, urinary α1- microglobulin （MG） and β2-MG were detected. The results showed that the level of plasma ADM rose gradually with the development of DN and was positively correlated with markers of tubulointerstiial injury such as urinary α1- MG and β2-MG （both P 〈0.05 ）, suggesting that ADM seems to play an important role in the development of the tubulointerstitial injury of DN.