α-硫辛酸对糖尿病周围神经病变的疗效

Efficacy ofα-lipoic acid in treating diabetic peripheral neuropathy

选择40例2型糖尿病并发糖尿病周围神经病变(DPN)患者分别静脉注射α-硫辛酸和甲钴胺连续2周,发现α-硫辛酸可以提高DPN患者神经传导速度,同时降低尿微量白蛋白、血浆内皮素和C反应蛋白,具有显著疗效,并且其疗效与甲钴胺相仿。

Forty type 2 diabetic patients with diabetic peripheral neuropathy （DPN） were assigned to two groups and treated respectively with α-lipoic acid or mecobalamin for 2 weeks. The results suggested that α-lipoic acid could accelerate the nerve conduction velocity and decrease the plasma level of endothelin and C reactive protein as well as microalbuminceria with a effect similar to mecobalamin therapy on DPN.