牙周感染与2型糖尿病患者血清白细胞介素-6水平的关系

The effect of periodontal infection on circulating IL-6 in type 2 diabetes patients

目的:探讨牙周感染对2型糖尿病患者血清白细胞介素-6(interleukin-6,IL-6)水平的影响。方法:选择伴重度慢性牙周炎的2型糖尿病患者32例,以年龄(±3)、性别、体重指数(body mass index,BMI)(±1)配比单纯糖尿病对照32例。用酶联免疫测定血清IL-6水平。结果:伴重度慢性牙周炎的2型糖尿病患者血清IL-6测定的阳性百分率明显高于不伴牙周炎的糖尿病患者(P=0.017)。结论:牙周感染可能升高2型糖尿病患者血清IL-6水平。

Objective： To investigate the effect of periodontal infection on circulating interleukin-6（IL-6） in type 2 diabetes patients. Methods： 32 diabetes patients with advanced periodontitis were participated, They were compared to a group of 32 diabetes patients without periodontal disease, who were matched with regard to age（ ± 3 ） , gender, and body mass index （ ± 1 ）. The serum concentration of IL-6 was measured by ELISA. Result：Differences were statistically significant between the two groups for serum IL-6 by Chi-square test （46.88% vs 18.75% , P 〈 0.05 ）. Conclusions： Periodontal infection may result in higher serum IL-6 in type 2 diabetes patients.