Astograph法测定100例慢性咳嗽患者的气道反应性

Measurement of airway responsiveness in 100 chronic cough patients by Astograph

目的:用Astograph法测定胸片正常的慢性咳嗽患者的气道反应性,并讨论其临床意义.方法:对确诊胸片正常的100例慢性咳嗽患者用AstographJ-21行气道反应性测定,组间差异用t检验分析,应用多重线性和逐步回归分析肺功能与激发指标间相关性.结果:100例慢性咳嗽患者,气道反应性测定阳性52例(52%,52/100),阴性48例(48%,48/100),经临床确诊CVA患者52例,气道反应测定均为阳性(100%,52/52).除FVC指标外(P>0.05),余肺功能指标两组间均有统计学差异(P<0.01).经回归分析,激发浓度指标与P50及BMI指数有相关.结论:Dmin,激发浓度与P50及BMI指数有相关.提示小气道指标对CVA的早期诊断具有一定提示意义.

AIM： To measure the airway responsiveness by astograph in chronic cough patients with normal X-ray results and to explore its clinical implications. METHODS： The airway responsiveness was measured by Astograph J-21 in 100 chronic cough patients with normal X-ray results. Data were analysed by SPSS 11.0 using student＇s t-test and the multiple linear and regression analyses. RESULTS. Fifty-two patients （52%, 52/ 100） had positive provocative results and 48 cases （48%, 48/ 100） were negative; 52 cough variant asthma （CVA） patients were finally cortfirmed and all the CVA patients had postive provocative results （100%, 52/52 ）. Pulmonary function indexes were found significantly different between the 2 groups （P 〈 0.01 ） except for FVC index （ P 〉 0.05 ）. Besides, P50 and the BMI index were found related to the concentration of provocative test （P 〈 0.05 ）. CONCLUSION： Dmin and provocative concentration are related to P50 and BMI, which possibly indicates that indexes of small airway tract function are more sensitive figures to identify CVA, especially to reveal early CVA.